Alzheimer's disease : new beginnings / edited by George Perry [and four others].

Format:

Book

Contributor:

Perry, George, 1953- editor.

Series:

Advances in Alzheimer's disease (Series) ; Volume 6.

Advances in Alzheimer's Disease ; Volume 6

Language:

English

Subjects (All):

Alzheimer's disease.

Physical Description:

1 online resource (682 pages).

Edition:

1st ed.

Place of Publication:

Amsterdam : IOS Press, [2018]

Summary:

Alzheimer's Disease: New Beginnings focuses on the future promise for therapeutic breakthroughs in light of notable clinical trial failures.The volume editors used a combination of scientometric evaluations to determine the most promising new approaches as well as soliciting insights from leaders in each of the major areas of Alzheimer's disease.

Contents:

Intro

Title Page

Preface

Contents

Clinical Trials for Disease-Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future

Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment

Lost in Translation? Finding Our Way To Effective Alzheimer's Disease Therapies

The End of the Beginning of the Alzheimer's Disease Nightmare: A Devil's Advocate's View

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease

Dementia Research: Populations, Progress, Problems, and Predictions

Three Decades of Dementia Research: Insights from One Small Community of Indomitable Rotterdammers

Religious Orders Study and Rush Memory and Aging Project

Prevention Matters: Time for Global Action and Effective Implementation

Multimodal Neuroimaging in Alzheimer's Disease: Early Diagnosis, Physiopathological Mechanisms, and Impact of Lifestyle

Preclinical Alzheimer's Disease: Implications for Refinement of the Concept

Nutritional Intervention as a Preventive Approach for Cognitive-Related Outcomes in Cognitively Healthy Older Adults: A Systematic Review

The Relationship between Obstructive Sleep Apnea and Alzheimer's Disease

From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease

Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: An Invaluable Tool for Clinical Diagnosis and Trial Enrichment

A Blood Test for Alzheimer's Disease: Progress, Challenges, and Recommendations

Potential Novel Approaches to Understand the Pathogenesis and Treat Alzheimer's Disease

Brain Inflammation Connects Cognitive and Non-Cognitive Symptoms in Alzheimer's Disease.

Toward a New Concept of Alzheimer's Disease Models: A Perspective from Neuroinflammation

Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET

Microglial Activation During Pathogenesis of Tauopathy in rTg4510 Mice: Implications for the Early Diagnosis of Tauopathy

Conquering Alzheimer's Disease by Self Treatment

Past to Future: What Animal Models Have Taught Us About Alzheimer's Disease

Iron and Alzheimer's Disease: An Update on Emerging Mechanisms

Brain Aging and Late-Onset Alzheimer's Disease: A Matter of Increased Amyloid or Reduced Energy?

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches

Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions

Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease

Perspectives on Oxidative Stress in Alzheimer's Disease and Predictions of Future Research Emphases

Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase

Findings from the Swedish Study on Familial Alzheimer's Disease Including the APP Swedish Double Mutation

Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease

Our Tau Tales from Normal to Pathological Behavior

Amyloid-Beta and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy

Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls.

The Amyloid-Beta Oligomer Hypothesis: Beginning of the Third Decade

Role of Amyloid-Beta and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade

Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer's Disease

Underlying Biological Processes in Mild Cognitive Impairment: Amyloidosis Versus Neurodegeneration

Amyloid-Beta/Drug Interactions from Computer Simulations and Cell-Based Assays.

Notes:

Description based on print version record.

Description based on publisher supplied metadata and other sources.

ISBN:

1-61499-876-0

OCLC:

1049711912