Toward the future : the new challenges of the cell therapy and potential of regenerative Medicine / edited by Nicola Daniele & Francesco Zinno.

Format:

Book

Author/Creator:

Daniele, Nicola, Author.

Contributor:

Zinno, Francesco, editor.

Daniele, Nicola, editor.

Language:

English

Subjects (All):

Stem cells--Research.

Stem cells.

Regeneration (Biology).

Physical Description:

1 online resource (170 pages) : illustrations, tables

Edition:

1st ed.

Place of Publication:

Sharjah, United Arab Emirates : Bentham eBooks, 2017.

Summary:

Cells are the building blocks of life and some cells (stem cells) have the ability to produce other cells through the processes of cell division and cell differentiation. Stem cell research has now progressed dramatically and there are countless studies published every year in scientific journals. Stem cell technology is being used to create new cell lines with edited genes and to regenerate cell based tissues for biological and medical purposes. This ebook presents a brief snapshot of clinical research in stem cell research and regenerative medicine. The concise reference is intended to be an introduction for biology students to current standards and new technologies in these fields.

Contents:

Intro

CONTENTS

FOREWORD

REFERENCES

PREFACE

List of Contributors

Biology of Human Stem Cells

INTRODUCTION

Embryonic Stem Cells

Adult Stem Cells

CONFLICT OF INTEREST

ACKNOWLEDEGEMENTS

Hematopoietic Stem Cells: Identification, Properties and Interest for Clinical Applications

Identification of the HSC and Role of the CD34 Antigen

Factors of Differentiation

Plasticity of Hematopoietic Stem Cells

Clinical Application

Stem Cell Therapy Applications: The Challenge of Regenerative Medicine

Hematopoietic Stem Cells in Therapy

Mesenchymal Stem Cells in Therapy

Therapeutic Applications

CONCLUDING REMARKS

ACKNOWLEDGEMENTS

Pluripotent Stem Cells: Basic Biology and Translational Medicine

THE CONCEPT OF PLURIPOTENCY

THE CONTRIBUTION OF ASSISTED REPRODUCTION TO THE PLURIPOTENT STEM CELL FIELD

PLURIPOTENT CELL TYPES

EC Cells

EG Cells

hESC

iPS

PLURIPOTENT CELLS IN DRUGS AND TOXICITY TESTING

PLURIPOTENT CELL BASED DISEASE MODELS

PLURIPOTENT CELLS RESEARCH BY SYSTEMS AND ORGAN

The Nervous System

The Cardiovascular System

Blood

Liver, Pancreas and Lungs

CELL THERAPY AND REGENERATIVE MEDICINE

Regenerative Therapies in the Eye

Heart Regeneration

Hematopoietic Precursors

Endodermal Tissues: Pancreas, Liver and Lungs

Central Nervous System

Exploiting the Role of Hematopoietic Stem Cell Transplantation as a Cure of Hematological and Non Hematological Diseases

Hematopoietic Stem Cells

Bone Marrow Microenvironment

Hematopoietic Stem Cell Transplantation.

Stem Cell Transplantation in Hematological Malignancies

Acute Myelogenous Leukemia (AML)

Myelodisplastic Syndromes (MDS)

Acute Lymphoblastic Leukemia (ALL)

Chronic Myelogenous Leukemia (CML)

Multiple Myeloma (MM)

Lymphoma

Hodgkin's Lymphoma (HL)

Non-Hodgkin Lymphomas (NHLs)

Diffuse Large B-cell Lymphoma (DLBCL)

Follicular Lymphoma (FL)

Mantle Cell Lymphoma (MCL)

Burkitt's Lymphoma (BL)

Stem Cell Transplantation in Non-neoplastic Hematological Malignancies

Severe Aplastic Anemia (SAA)

Inherited Bone Marrow Failure Syndromes (IBMFS)

Hemoglobin Diseases

Stem Cell Transplantation in Solid Tumors

Germ Cell Tumors

Ewing and Ewing-like Sarcomas

Neuroblastoma

HSCT in Immunedeficiencies, Inherited Metabolic Disorders and Autoimmune Diseases Transplantation in Immunedeficiencies

Transplantation in Inborn Metabolic Errors

Autoimmune Diseases

CONCLUSION AND FUTURE PERSPECTIVES

Human Induced Pluripotent Stem Cells-Based Strategies: New Frontiers for Personalized Medicine

1. GENERATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSCS)

2. GENE EDITING

2.1. Zinc Finger Nuclease (ZFNs)

2.2. TALENS

2.3. CRISPR/Cas9

3. PERSONALIZED MEDICINE

GLOSSARY

Stem Cells for Therapeutic Delivery of Mediators and Drugs

Mesenchymal Stem Cells (MSCs) - Background

Advantages/Disadvantages of MSCs in Drug Delivery for Cancer

Exosomes

Gap Junctional Intercellular Communication (GJIC)

Drug Delivery - Potential Approaches and Gaps

CONCLUSION

SUBJECT INDEX.

Notes:

Includes bibliographical references and index.

Description based on online resource; title from PDF title page (ebrary, viewed April 25, 2017).

ISBN:

9781681084374

1681084376