Staphylococcus : genetics and physiology / edited by Greg A. Somerville.

Format:

Book

Contributor:

Somerville, Greg A., editor.

Language:

English

Subjects (All):

Staphylococcus aureus.

Physical Description:

1 online resource (400 pages)

Edition:

1st ed.

Place of Publication:

Norfolk, UK : Caister Academic Press, [2016]

Summary:

This book brings together respected S. aureus experts from around the world to provide a timely overview of staphylococcal research. Topics covered include: historical background; medical significance in humans and animals; genetic variation; virulence factors; metabolism and physiology; physiological proteomics; cell wall assembly and physiology; transition metal ion homeostasis; molecular strategies of antibiotic resistance; genetic regulation; and immune response. Essential reading for scientists working with staphylococci. This text is an excellent introduction for entry level scientists, as well as those seeking a deeper understanding of this critically important bacterial pathogen.

Contents:

Intro

Contents

Contributors

Preface

Current Books of Interest

1. History of Staphylococcus aureus

Introduction

Discovery: identification and classification

Mapping of the S. aureus genome

Pathogenesis

Urinary tract infections

Vaccines and immunity

Antibiotic efficacy and resistance

Meetings

Conclusions

2. Clinical Significance in Humans

Staphylococci: a short description of the species

Staphylococci: natural commensals of humans

Staphylococcal disease: clinically important manifestations

3. Staphylococcus: Clinical Significance in Animals

Staphylococci as veterinary pathogens

Virulence factors

Staphylococcus aureus infections in animals

Staphylococcus intermedius group (SIG) and associated diseases

Coagulase-negative staphylococci

Treatment of veterinary staphylococci infections

Antimicrobial resistance in veterinary staphylococci

Methicillin-resistant Staphylococcus pseudintermedius

Conclusions and future trends

4. Staphylococcal Variation and Evolution

The S. aureus genome

Variation between isolates

Variation: mechanisms

Selection

Other staphylococcal species

Technology

Conclusions and future

5. Staphylococcal Virulence Factors

Colonization: teichoic acids and microbial surface components recognizing adhesive matrix molecules (MSCRAAMs)

Superantigens (SAgs) and exfoliative toxins (ETs): systemic defence against the human immune system

Cytotoxins: the second line of defence against the human immune system

Third line of S. aureus defence against the human immune system

6. Staphylococcus aureus Metabolism and Physiology

Cultivation of Staphylococcus aureus

Staphylococcal growth phases and changes in metabolism.

Staphylococcus aureus metabolism

Glycolysis

Pentose phosphate pathway

Tricarboxylic acid cycle

Gluconeogenesis

Amino sugar biosynthesis

Amino acid synthesis

Nucleic acid synthesis

Conclusion

7. Physiological Proteomics of Staphylococcus aureus: from the Protein Inventory to Stress Physiology and in vivo Adaptation

The protein inventory of S. aureus

S. aureus proteomic signatures: towards an understanding of S. aureus adaptation to the human host during colonization and infection

Concluding remarks

8. Cell Wall Assembly and Physiology

S. aureus membrane lipids and their synthesis

S. aureus peptidoglycan structure, synthesis and function

Cell wall proteins in S. aureus

Teichoic acids in S. aureus

Exopolysaccharides in S. aureus

Cell wall synthesis inhibitors and resistance mechanisms

9. Transition Metal Ion Homeostasis

Iron

Manganese

Zinc

Nickel and cobalt

Avoiding excess: mechanisms of defence against toxic metals

The importance of metal ion homeostasis in the host

Host iron metabolism

Host Mn, Cu and Zn metabolism

10. Stress Responses in Staphylococcus aureus

The heat shock response: a general response to protein damage

The SigB regulon

Oxidative stress

DNA damage response

Osmotic stress

Cold stress

The stringent response

Cell envelope stress

11. Molecular Strategies of Staphylococcus aureus for Resisting Antibiotics

Resistance to antibiotics used in the therapy of S. aureus infection

Discussion

12. Genetic Regulation

Two-component systems

The Sar family of DNA-binding proteins

Metabolite responsive elements

Alternative σ factors

Regulatory RNAs.

Conclusions and future trends

13. Immune Response to Staphylococcus aureus

Innate immune response to bacterial infection

Adaptive immune response to bacterial infection

Immune regulation

Why immunity fails: immune evasion and immunodeficiency

Immunological memory and protective immunity

Anti-S. aureus vaccines

Index.

Notes:

Description based on print version record.

ISBN:

1-910190-50-0