Key chiral auxiliary applications / Gregory Roos.

Format:

Book

Author/Creator:

Roos, Gregory.

Language:

English

Subjects (All):

Asymmetric synthesis.

Enantioselective catalysis.

Enantiomers.

Physical Description:

1 online resource (1271 p.)

Edition:

2nd ed.

Place of Publication:

Waltham, [Massachusetts] ; Amsterdam, The Netherlands : Academic Press, 2014.

Language Note:

English

Summary:

Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of resul

Contents:

Front Cover; Key Chiral Auxiliary Applications; Copyright; CONTENTS; ACKNOWLEDGEMENTS; FOREWORD; PREFACE TO THE 2ND EDITION; ABBREVIATIONS; 1.INTRODUCTION; 1.1. BACKGROUND; 1.2. THE CHIRAL AUXILIARY APPROACH; 1.3. THIS COLLECTION; REFERENCES; 2.ALKYLATION AND RELATED REACTIONS I; 2.1 ALLYL AND BENZYL RELATED CARBANIONS; 2.2 ALLENIC ETHER TANDEM ACYLATION-CYCLIZATION; 2.3 ALDEHYDE DERIVED NUCLEOPHILES; 2.4 KETONE DERIVED NUCLEOPHILES; 2.5 ALDEHYDE AND KETONE ENOLATES WITH AUXILIARY-CONTAINING ELECTROPHILES; REFERENCES; 3.ALKYLATION AND RELATED REACTIONS II

3.1 α-ALKYLATION OF CARBOXYLIC ACID DERIVED NUCLEOPHILESREFERENCES; 4.ALKYLATION AND RELATED REACTIONS III; 4.1 α-ALKYLATION OF -HETEROATOM SUBSTITUTED ACID DERIVATIVES; 4.2 α-ALKYLATION OF CYCLIC CARBOXYLIC ACID DERIVATIVES; REFERENCES; 5.ALKYLATION AND RELATED REACTIONS IV; 5.3 α-HYDROXYLATION OF ACID DERIVATIVES; 5.1 α-ACYLATION OF ACID DERIVATIVES; 5.2 α-AMINATION OF ACYL DERIVATIVES; 5.4 α-SILYLATION, α-THIOLATION, AND α-SELENATION OF ACID DERIVATIVES; 5.5 α-HALOGENATION OF ACID DERIVATIVES; 5.6 REACTION OF PHOSPHORIC ACID DERIVATIVES WITH ELECTROPHILES

5.7 α-ALKYLATION OF SULFONIC ACID DERIVATIVES5.8 AROMATIC SUBSTITUTION; 5.9 NUCLEOPHILIC ALLYLIC SUBSTITUTION; 5.10 MISCELLANEOUS REACTIONS; REFERENCES; 6.ELECTROPHILIC RELATED ADDITION TO C=C; 6.1 REDUCTION AND RELATED REACTIONS; 6.2 ADDITION OF HALO-CONTAINING ADDENDS; 6.3 BISAMINATION; 6.4 ADDITION OF OXY-ADDENDS; 6.5 CYCLOPROPANATION; 6.6 CYCLOPROPENATION; 6.7 AZIRIDINATION; 6.8 ALKOXYSELENATION; 6.9 RADICAL ADDITION; REFERENCES; 7.CONJUGATE ADDITION I; 7.1 AUXILIARY ON DONOR NUCLEOPHILE - SIMPLE ADDITION; 7.2 AUXILIARY ON DONOR NUCLEOPHILE - TANDEM ADDITION; REFERENCES

8.CONJUGATE ADDITION II8.1 AUXILIARY ON ACCEPTOR α,β-UNSATURATED SYSTEM - SIMPLE ADDITION; REFERENCES; 9.CONJUGATE ADDITION III; 9.1 α,β-UNSATURATED ACYL DERIVATIVES - ADDITION OF HETERONUCLEOPHILES; 9.2 OTHER ACTIVATED SYSTEMS; 9.3 INTRAMOLECULAR REACTIONS; 9.4 AUXILIARY ON α,β-UNSATURATED SYSTEM - TANDEM ADDITION OFCARBON NUCLEOPHILES; 9.5 AUXILIARY ON ACCEPTOR α,β-UNSATURATED SYSTEM - TANDEM ADDITION OFHETERONUCLEOPHILES; 9.6 AUXILIARY ON ACCEPTOR α,β-UNSATURATED SYSTEM - RADICAL ADDITION; 9.7 NUCLEOPHILIC ADDITION TO TRANSITION-METAL ALKENE/ARENE COMPLEXES; REFERENCES

10.ADDITION TO C=N BONDS10.1 REDUCTION OF IMINES, IMINIUM IONS, HYDRAZONES AND OXIMES; 10.2 NUCLEOPHILIC ADDITION; 10.3 RADICAL ADDITION; 10.4 UGI COUPLING; REFERENCES; 11.ADDITION TO C=O BONDS I; 11.1 REDUCTION; 11.2 WITTIG & RELATED OLEFINATION; 11.3 ADDITION OF ORGANOMETALLIC AND RELATED REAGENTS; REFERENCES; 12.ADDITION TO C=O BONDS II; 12.1 ADDITION OF ENOLATES (ALDOL AND RELATED REACTIONS); REFERENCES; 13.ADDITION TO C=O BONDS III; 13.1 ADDITION OF ENOLATES (ALDOL AND RELATED REACTIONS); 13.2 TANDEM REACTIONS; 13.3 RADICAL REACTIONS; REFERENCES; 14. CYCLOADDITIONS I

14.1 [2+2]-CYCLOADDITIONS

Notes:

Description based upon print version of record.

Includes bibliographical references.

Description based on online resource; title from PDF title page (ebrary, viewed March 04, 2014).

ISBN:

0-12-417115-X

OCLC:

870949356