Conceptual design of crystallization processes / Christianto Wibowo, Ka Ming Ng.

Format:

Book

Author/Creator:

Wibowo, Christianto, 1972- author.

Ng, Ka Ming, author.

Series:

De Gruyter STEM

Language:

English

Subjects (All):

Crystallization.

Separation (Technology).

Physical Description:

xviii, 349 pages : illustrations ; 24 cm.

Place of Publication:

Berlin ; Boston : De Gruyter, [2021]

Contents:

1.1 Crystallization in the Chemical Processing Industries p. 1

1.2 Crystallization as a Multiscale Design Problem p. 3

1.3 An Integrative Approach to Crystallization Process Design p. 4

2 Basics of Solid-Liquid Equilibrium Phase Behavior p. 9

2.1 Solid-Liquid Equilibrium p. 9

2.1.1 Melting point and solubility p. 9

2.1.2 Phase diagram and Gibbs phase rule p. 10

2.2 Molecular Systems p. 11

2.2.1 Single component systems p. 11

2.2.2 Binary systems p. 12

2.2.3 Ternary systems p. 19

2.2.4 Quaternary systems p. 24

2.2.5 Multicomponent systems p. 28

2.2.6 Reactive systems p. 35

2.3 Electrolyte Systems p. 39

2.3.1 Acid-base systems p. 42

2.3.2 Conjugate salt systems p. 44

2.3.3 Multicomponent salt system p. 48

3 Thermodynamic-Based Conceptual Design of Crystallization Processes p. 57

3.1 Movements in Composition Space p. 57

3.1.1 Lever rule p. 58

3.1.2 Representation of basic operations on SLE phase diagram p. 60

3.2 Maximum Recovery of a Pure Solid p. 62

3.3 Crystallization of Desirable Product p. 73

3.4 Complete Dissolution p. 79

4 Synthesis of Crystallization-Based Separation Processes p. 89

4.1 Crystallization as a Separation Process p. 89

4.2 Bypassing the Thermodynamic Boundary p. 89

4.2.1 Ternary system p. 89

4.2.2 Quaternary system p. 97

4.2.3 Multicomponent system p. 100

4.2.4 Conjugate salt system p. 102

4.3 Effect of Solvent p. 109

4.3.1 Solvent selection p. 109

4.3.2 Solvent switching p. 111

4.4 Hybrid Separation Process p. 113

5 Crystallization Processes Involving More Complex Phase Behaviors p. 126

5.1 Adductive Crystallization p. 126

5.1.1 SLE phase behavior involving adduct p. 126

5.1.2 Process synthesis p. 127

5.2 Chiral Resolution by Crystallization p. 131

5.2.1 SLE phase behavior of chiral systems p. 132

5.2.2 Process synthesis p. 134

5.2.3 Hybrid process for chiral resolution p. 138

5.3 Solid Solution Crystallization p. 141

5.3.1 SLE phase behavior of solid solution systems p. 141

5.3.2 Process synthesis p. 142

5.4 Amino Acid and Protein Crystallization p. 149

5.4.1 SLE phase behavior of amino acid systems p. 149

5.4.2 Process synthesis p. 151

5.5 Antisolvent Crystallization p. 156

5.5.1 Solid-liquid-liquid equilibrium phase behavior p. 156

5.5.2 Process synthesis p. 159

5.6 Supercritical Fluid Crystallization p. 162

5.6.1 Solid-fluid equilibrium phase behavior p. 162

5.6.2 Process synthesis p. 166

6 Impact of Kinetics and Mass Transfer on Crystallization p. 176

6.1 Kinetic Effects in Crystallization Process p. 176

6.1.1 Supersaturation p. 176

6.1.2 Nucleation and growth models p. 177

6.2 Actual Process Path p. 179

6.3 Preferential Crystallization p. 181

6.4 Kinetically Controlled Reactive Crystallization p. 184

6.5 Polymorphic Crystallization p. 190

6.5.1 SLE phase behavior of polymorphic systems p. 191

6.5.2 Process synthesis p. 193

7 Management of Particle Size Distribution and Impurities in Crystallization Processes p. 207

7.1 Crystallizer Model p. 207

7.1.1 Population balance p. 207

7.1.2 Solutions of population balance equations p. 210

7.2 Particle Size Distribution Management p. 211

7.2.1 PSD manipulation in batch crystallization p. 211

7.2.2 PSD targeting in continuous crystallization p. 220

7.2.3 Scale-up consideration in PSD management p. 225

7.3 Impurity Management p. 227

7.3.1 Control of inclusion impurities p. 228

7.3.2 Removal of inclusion impurities by melt crystallization p. 233

7.3.3 Crystallization downstream processing system p. 238

7.3.4 Simultaneous washing and melt crystallization p. 244

8 Determination of Solid-Liquid Equilibrium Phase Behavior and Crystallization Kinetics p. 253

8.1 Strategy for SLE Phase Behavior Determination p. 253

8.2 Modeling of SLE Phase Behavior p. 254

8.2.1 Solubility equation and solubility product equation p. 255

8.2.2 Activity coefficient models p. 260

8.2.3 Equation of!state models p. 260

8.3 Prediction of Solid-Liquid Equilibrium Phase Behavior p. 264

8.3.1 Group contribution methods p. 264

8.3.2 Quantum chemistry methods p. 270

8.4 Experimental Determination of SLE Phase Behavior p. 270

8.4.1 Thermal method for obtaining SLE data p. 271

8.4.2 Synthetic method for obtaining SLE data p. 276

8.4.3 Analytical method for obtaining SLE data p. 279

8.4.4 Fitting of model parameters p. 280

8.4.5 Boundary verification p. 287

8.5 Experimental Determination of Crystallization Kinetics p. 292

9.1 A Hierarchical, Multiscale, Integrative Approach p. 300.

Notes:

Includes bibliographical references and index.

ISBN:

9781501519871

1501519875

OCLC:

1162536706