Thermostable proteins : structural stability and design / Srikanta Sen, Lennart Nilsson.

Format:

Book

Author/Creator:

Sen, Srikanta.

Contributor:

Nilsson, Lennart, 1952 November 11-

Language:

English

Subjects (All):

Protein engineering.

Proteins--Analysis.

Proteins.

Physical Description:

1 online resource (184 p.)

Edition:

1st edition

Place of Publication:

Boca Raton : Taylor & Francis, 2011.

Language Note:

English

System Details:

text file

Summary:

Thermostable Proteins: Structural Stability and Design provides a comprehensive, updated account of the physical basis of enhanced stability of thermophilic proteins and the design of tailor-made thermostable proteins, paving the way for their possible industrial applications. This book is devoted to understanding the survival mechanisms of thermophilic life forms at the molecular level with an emphasis on design strategies.The review chapters presented in Thermostable Proteins span a wide range of protein thermostability research. Basic structural, thermodynamic, and kinetic principles are explained and molecular strategies for the adaptation to high temperatures are delineated. In addition, this book covers: computing and simulation methods in current and future thermostability research, especially in nonempirical situations, how rigidity theory is used to improve the thermal adaptation of mesophiles Subtilisin-like serine proteases and their significant engineering applications. The state of knowledge concerning structure function relations and the origins of their structural stability. Computational and experimental approaches for the design of proteins with increased thermal stability based on sequences or three-dimensional structures. Understanding the molecular basis of how thermostable and hyperthermostable proteins gain and maintain their stability and biological function at high temperatures remains an important scientific challenge. A more detailed knowledge of protein stability not only deepens our understanding of protein structure but also helps in obtaining insights into processes that drive protein activities folding, unfolding, and misfolding essential to biological function--Provided by publisher.

Contents:

Front Cover; Contents; Foreword; Contributors; Chapter 1: Delineation of the Conformational Thermostability of Hyperthermophilic Proteins Based on Structural and Biophysical Analyses; Chapter 2: Role of Packing, Hydration, and Fluctuations on Thermostability; Chapter 3: Analyzing Protein Rigidity for Understanding and Improving Thermal Adaptation; Chapter 4: Thermostable Subtilases (Subtilisin-Like Serine Proteinases); Chapter 5: Combined Computational and Experimental Approaches to Sequence-Based Design of Protein Thermal Stability

Chapter 6: Designing Thermophilic Proteins: A Structure-Based Computational ApproachBack Cover

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613274533

9781040053577

1040053572

9780429064128

0429064128

9781283274531

1283274531

9781439839140

143983914X

OCLC:

756484229