Biased signaling at mu opioid receptor splice variants / Ying-Xian Pan.

Format:

Video

Author/Creator:

Pan, Ying-Xian, (Memorial Sloan-Kettering Cancer Center, USA), speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. G Protein-Coupled Receptors (GPCRs) signaling in health and disease.

G Protein-Coupled Receptors (GPCRs) signaling in health and disease, 2056-452X

Language:

English

Subjects (All):

Cellular signal transduction.

G proteins--Receptors.

G proteins.

Opioids--Receptors.

Opioids.

Alternative Splicing.

Drug Tolerance.

Morphine.

OPRM1 protein, human.

Receptors, G-Protein-Coupled--metabolism.

Receptors, Opioid, mu--genetics.

Receptors, Opioid, mu--metabolism.

Signal Transduction.

Medical Subjects:

Alternative Splicing.

Drug Tolerance.

Morphine.

OPRM1 protein, human.

Receptors, G-Protein-Coupled--metabolism.

Receptors, Opioid, mu--genetics.

Receptors, Opioid, mu--metabolism.

Signal Transduction.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (42 min.)) : color, sound.

polychrome

Place of Publication:

London : Henry Stewart Talks, 2020.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: Extensive alternative pre-mRNA splicing of the mu opioid receptor gene (OPRM1)

Distinct intracellular C-terminal tails in different full-length 7TM C-terminal variants

Distinct in vivo functions of several C-terminal tails

In vivo truncation of C-terminal tails encoded by E7 affects morphine tolerance and reward

In vivo truncation of C-terminal tails encoded by E4 affects morphine tolerance and dependence.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

4868 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.