Clinical Xenotransplantation : Pathways and Progress in the Transplantation of Organs and Tissues Between Species / edited by David K. C. Cooper, Guerard Byrne.

Format:

Book

Contributor:

Cooper, D. K. C. (David K. C.), 1939- editor.

Byrne, Guerard, editor.

SpringerLink (Online service)

Series:

Medicine (SpringerNature-11650)

Language:

English

Subjects (All):

Surgery.

Hepatology.

Microbiology.

Immunology.

Local Subjects:

Surgery.

Hepatology.

Microbiology.

Immunology.

Physical Description:

1 online resource (XXIX, 306 pages) : 82 illustrations, 59 illustrations in color

Edition:

First edition 2020.

Contained In:

Springer Nature eBook

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2020.

System Details:

text file PDF

Summary:

This title provides an illuminating examination of the current state of xenotransplantation - grafting or transplanting organs or tissues between members of different species - and how it might move forward into the clinic. To be sure, this is a critical topic, as a major problem that remains worldwide is an inadequate supply of organs from deceased human donors, severely limiting the number of organ transplants that can be performed each year. Based on presentations given at a major conference on xenotransplantation, this title includes important views from many leading experts who were invited to present their data and opinions on how xenotransplantation can advance into the clinic. Attention was concentrated on pig kidney and heart transplantation as it is in regard to these organs that most progress has been made. Collectively, these chapters effectively highlight the many advantages of xenotransplantation to patients with end-stage organ failure, thereby encouraging the mapping of a concrete pathway to clinical xenotransplantation. The book is organized across 22 chapters, beginning with background information on clinical and experimental xenotransplantation. Following this are discussions addressing how pigs can be genetically engineered for their organs to be resistant to the human immune response through deletion of pig xenoantigens, and the insertion of 'protective' human transgenes. Subsequent chapters analyze complications that arise in practice, comparing allotransplant and xenotransplant rejection. The selection of the ideal patients for the first clinical trials is discussed. Finally, the book concludes with an analysis on the regulatory, economic, and social aspects of this research, including FDA perspectives and the sensitive, psychosocial factors regarding allotransplantation and xenotransplantation. A major and timely addition to the literature, Clinical Xenotransplantation will be of great interest to all researchers, physicians, and academics from other disciplines with an interest in xenotransplantation.

Contents:

Clinical and Experimental Xenotransplantation: Background

1. A brief history of clinical cross-species organ xenotransplantation

2. The pathobiology of pig-to-primate xenotransplantation: a historical review

3. Is sensitization to pig antigens detrimental to subsequent allotransplantation?

4. Sensitization to human leukocyte antigens and xenotransplantation?

Pig Kidney and Heart Xenotransplantation in Nonhuman Primates - the Present Position

5. Kidney xenotransplantation in nonhuman primates

6. Cardiac xenotransplantation in nonhuman primates

Organ-source Pig Genetic Engineering and Regulation

7. Gene-edited pigs for xenotransplantation

8. Addressing regulatory requirements for the organ-source pig - a pragmatic approach to facility design and pathogen prevention

Antibody-Mediated Allotransplant Rejection: Lessons for Xenotransplantation

9. Antibody-mediated graft rejection in nonhuman primate models: comparison of sensitized allotransplant and xenotransplant rejection

10. Management of anti-HLA antibodies and acute antibody-mediated rejection

11. Evolving approaches to treatment of allosensitization and antibody-mediated rejection

12. Lessons from ABO-incompatible cardiac allotransplantation in the newborn

Patient Evaluation and Selection for First Clinical Trials of Kidney or Heart Xenotransplantation

13. Defining an "acceptable risk threshold" - who should be the first kidney xenotransplant recipient?

14. Selection of patients for initial clinical trials of kidney xenotransplantation

15. Selection of patients for initial clinical trials of cardiac xenotransplantation

16. Selection of pediatric patients for initial clinical trials of cardiac xenotransplantation

17. Infection in xenotransplantation: organ-source health and patient safety

18. Histocompatibility testing for xenotransplantation

Regulatory, Economic, and Social Aspects of Clinical Trials of Xenotransplantation

19. Xenotransplantation; the FDA perspective

20. Xenotransplantation: a payer's perspective

21. Public perceptions towards clinical trials of organ xenotransplantation

Summation

22. What did the workshop achieve?

Other Format:

Printed edition:

ISBN:

978-3-030-49127-7

9783030491277

Access Restriction:

Restricted for use by site license.