Uremic Toxins and Organ Failure / edited by Hideyuki Saito, Takaaki Abe.

Format:

Book

Contributor:

Saito, Hideyuki, editor.

Abe, Takaaki, editor.

SpringerLink (Online service)

Series:

Medicine (SpringerNature-11650)

Language:

English

Subjects (All):

Nephrology.

Gastroenterology.

Cardiology.

Local Subjects:

Nephrology.

Gastroenterology.

Cardiology.

Physical Description:

1 online resource (VIII, 180 pages) : 39 illustrations, 22 illustrations in color

Edition:

First edition 2020.

Contained In:

Springer Nature eBook

Place of Publication:

Singapore : Springer Singapore : Imprint: Springer, 2020.

System Details:

text file PDF

Summary:

This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.

Contents:

1 Overview of Uremic Toxins

2 Review: Uremic toxins and gut microbiome

3 Gut microbiota and systemic uremic solute accumulation

4 Uremic toxin-related systemic disorders

5 Uremic Toxins and cardiovascular disease

6 Indoxyl sulfate and arteriosclerosis

7 Uremic Toxicity and Bone in CKD

8 D-serine as a novel uremic toxin

9 Uremic solutes and sarcopenia

10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries

11 Accumulation of uremic toxins in systemic organs and the effect of AST-120.

Other Format:

Printed edition:

ISBN:

978-981-15-7793-2

9789811577932

Access Restriction:

Restricted for use by site license.