Chasing men on fire : the story of the search for a pain gene / Stephen G. Waxman ; foreword by James E. Rothman.

Format:

Book

Author/Creator:

Waxman, Stephen G., author.

Series:

MIT Press Ser.

The MIT Press Ser.

Language:

English

Subjects (All):

Pain--Genetic aspects.

Pain.

Pain--Treatment.

Physical Description:

1 online resource (pages).

Place of Publication:

Cambridge, MA : The MIT Press, [2018]

System Details:

text file

Summary:

A thirty-year quest, from genes to pain-signaling neurons to people with a rare genetic disorder that makes them feel they are on fire.

Contents:

Part I Dissecting God's Megaphone 1

1 Dissecting God's Megaphone: The Search for a Pain Gene 3

2 Sherrington's Enchanted Loom and Huxley's Science Fiction 9

Part II Chasing Men on Fire: The Search 23

3 Alabama to Beijing ... and Back 25

Cummins et al.: Electrophysiological Properties of Mutant Na_v1.7 Sodium Channels in a Painful Inherited Neuropathy 35

Dib-Hajj et al.: Gain-of-Function Mutation in Na_v1.7 in Familial Erythromelalgia Induces Bursting of Sensory Neurons 45

4 Avalanche 57

Dib-Hajj et al.: The Na_v1.7 Sodium Channel: From Molecule to Man 61

5 Two Sides of One Coin 85

Rush et al.: A Single Sodium Channel Mutation Produces Hyper- or Hypoexcitability in Different Types of Neurons 89

6 Eavesdropping 103

Vasylyev et al.: Dynamic-Clamp Analysis of Wild-Type Human Na_v1.7 and Erythromelalgia Mutant Channel L858H 109

Part III Beyond the Search: Expanding Horizons 133

7 Twisted Nerve: A Ganglion Gone Awry 135

Black et al.: Multiple Sodium Channel Isoforms and Mitogen-Activated Protein Kinases Are Present in Painful Human Neuromas 139

8 Crossing Borders 155

9 From Zebras to Horses 163

Faber et al.: Gain of Function Na_v1.7 Mutations in Idiopathic Small Fiber Neuropathy 175

Persson et al.: Neuropathy-Associated Na_v1.7 Variant I228M Impairs Integrity of Dorsal Root Ganglion Neuron Axons 195

Part IV Muting God's Megaphone: From the Squid Toward the Clinic 213

11 Seven Years from Theory toward Therapy ... via "Pain in a Dish" 215

Cao et al.: Pharmacological Reversal of a Pain Phenotype in iPSC-Derived Sensory Neurons and Patients with Inherited Erythromelalgia 225

12 From Trial-and-Error to First-Time-Around: Toward Genomically Guided Therapy 247

Yang et al.: Structural Modelling and Mutant Cycle Analysis Predict Pharmacoresponsiveness of a Na_v1.7 Mutant Channel 251

13 Precision 271

Geha et al.: Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling 275

14 "The Important Thing Is Not to Stop" 289.

Notes:

OCLC-licensed vendor bibliographic record.

ISBN:

9780262344722

0262344726

OCLC:

1028188541

Access Restriction:

Restricted for use by site license.