Proteomics : targeted technology, innovations and applications / Edited by Manuel Fuentes and Joshua LaBaer.

Format:

Book

Contributor:

LaBaer, Joshua, editor.

Fuentes, Manuel (Biochemist), editor.

Language:

English

Subjects (All):

Proteomics.

Physical Description:

1 online resource (197 p.)

Edition:

1st ed.

Place of Publication:

Norfolk, England : Caister Academic Press, [2014]

Language Note:

English

Summary:

Targeted proteomics is a technology for detecting proteins of interest with high sensitivity, quantitative accuracy, and reproducibility. The analysis of a pre-defined group of proteins provides precise, quantitative, and sensitive data to scientists and clinicians and can provide information on a subset of proteins important for their biological function. In this volume, a panel of high-profile contributors provides an overview of targeted proteomics in biomedical science. The book is focused on current state-of-the-art technology and applications, and it will be a valuable source of informat

Contents:

Contents; Contributors; Current books of interest; Preface; 1: Serum Proteomics for Studying Disease Pathogenesis and Identification of Disease Biomarkers; Introduction; Challenges of serum proteome analysis; Proteomic techniques in serum profiling; Applications; Conclusion; 2: Serum Profiling by Targeted Proteomics for Biomarker Discovery; Biomarker discovery; Targeted proteomics; Serum profiling by targeted proteomics; Conclusions; 3: Targeted Proteomics: Applications in the Study of Liver Disorders; The liver; Shotgun proteomics and liver disorders

MS-based targeted proteomics: selected reaction monitoring for protein detection and quantitationProtein regulation: targeted analysis of post-translational modifications based on enrichment procedures; Concluding remarks and future perspectives; 4: Targeted Proteomics for Chronic Lymphocytic Leukaemia; Introduction; Epidemiology and incidence; Clinical presentation; Monoclonal B lymphocytosis (MBL); Genetic and epigenetic analysis of CLL; Proteomics profiles in B-cell malignancies; Proteome analysis of B-cell maturation; Quantitative proteomics

'shot gun' proteomic studies on B-cell malignanciesConclusions and future directions; 5: Protein Microarrays: A Versatile Tool for Scientific Discovery; Introduction; Basic research applications; Clinical research applications; Data analysis and bioinformatics; Outlook and perspective; 6: Bioinformatics Challenges in Targeted Proteomics; Introduction; Experimental design; Data acquisition and data processing; Noise reduction and normalization; Data interpretation

7: Standardized Formats, Report Information Guidelines, Mass Spectrometry-based Repositories and Application Programming Interfaces for Implementing Data Standards in ProteomicsBackground: HUPO-PSI; Standardization pillars: MIAPE guidelines, XML-based standard formats and controlled vocabularies; Proteomics repositories and databases; Application Programming Interfaces (APIs) for the integration of data standards into laboratory pipelines; Bioinformatics tools for creating and managing proteomics data standards; Data analysis and reporting tools; Conclusions

8: Clinical Protein Science and Targeted Mass Spectrometric Assays - New Frontiers in Disease Link and BiobankingThe unmet needs and progresses in modern healthcare; Building new medical frontiers in modern society; Impact to society of personalized medicines; Biobanking; Protein biomarkers and targeted analysis; Prostate cancer protein biomarker analysis; Conclusions; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-908230-62-2

OCLC:

884590354