Aspergillus and penicillium in the post-genomic era / edited by Ronald P. de Vries, Isabelle Benoit Gelber and Mikael Rordam Andersen.

Format:

Book

Contributor:

Vries, Ronald P. de, editor.

Gelber, Isabelle Benoit, editor.

Andersen, Mikael Rørdam, editor.

Language:

English

Subjects (All):

Aspergillus--Genetics.

Aspergillus.

Penicillium--Genetics.

Penicillium.

Physical Description:

1 online resource (220 pages)

Edition:

1st ed.

Place of Publication:

Norfolk, UK : Caister Academic Press, [2016]

Summary:

This book highlights some of the changes in the studies into these fungi, since the availability of genome sequences. The contributions vary from insights in the taxonomy of these genera, use of genomics for forward genetics and genomic adaptations, to specific stories addressing virulence, carbon starvation, sulphur metabolism, feruloyl esterases, secondary metabolism and pH modulation, to the development of novel methodology for use in parallel to genome sequencing. It therefore provides a taste of the current status of research in Penicillium and Aspergillus and a promise of many more things to come. An essential reference for everyone working with Aspergillus and Penicillium and other filamentous fungi and the book is also recommended reading for everyone with an interest in fungal genomics.

Contents:

Intro

Contents

Contributors

Current Books of Interest

Preface

1. Taxonomy of Aspergillus, Penicillium and Talaromyces and its Significance for Biotechnology

Introduction

Phylogeny of Eurotiales

Species and species concepts

Single name nomenclature and its impact on applied mycology

New species, new names

Aspergillus, Penicillium and Talaromyces and related genera

Conclusion

2. Comparative Genomics, Resequencing and Fast Forward Genetics in Aspergillus and Penicillium

Resequencing and fast forward genetics

The aspergilli

Penicillium

Conclusions

Future trends

3. Diversity and Mechanisms of Genomic Adaptation in Penicillium

Ecological niches and life history traits

Phylogenetic relationships, genome size and content, and changes in gene content

Horizontal gene transfers

Transcriptomics

Population genetic diversity within Penicillium species and mode of reproduction

Conclusions and future prospects

4. Approaches for Comparative Genomics in Aspergillus and Penicillium

Current status of genomics

Available genome databases with comparative genomics capabilities

General methods for comparative genomics

Primary metabolism

Secondary metabolism

Secretome analysis and plant polysaccharide degradation

Other comparative 'omics'

Future perspectives - what can we learn from bacteria?

5. Blue Mould to Genomics and Beyond: Insights into the Biology and Virulence of Phytopathogenic Penicillium Species

Current status of blue mould research

Current status of Penicillium genomics

6. Post-genomic Approaches to Dissect Carbon Starvation Responses in Aspergilli

Controlled cultivation of filamentous fungi to study starvation responses.

Carbon starvation responses

Morphological responses during C-limitation

Recycling responses to deal with carbon starvation

Co-regulation of conidiogenesis and cell wall hydrolase production

Regulation of extracellular protease formation during carbon starvation

Conclusions and future trends

7. Genetics and Physiology of Sulfur Metabolism in Aspergillus

Synthesis of cysteine and methionine

Sulfur metabolite repression

Dysregulation of sulfur metabolism in cys and scon mutants induces stress responses

Transcription factors controlling sulfur metabolism

Other regulatory systems in sulfur metabolism

8. Production of Feruloyl Esterases by Aspergillus Species

Materials and methods

Results

Discussion

9. Secondary Metabolite Formation by the Filamentous Fungus Penicillium chrysogenum in the Post-genomic Era

Fungal secondary metabolite enzymes

Secondary metabolite gene clusters and their products in P. chrysogenum

Approaches for the activation of 'silent' secondary metabolite gene clusters

10. pH Modulation by Fungal Secreted Effecting Molecules: A Mechanism Affecting Pathogenicity and Mycotoxin Accumulation During Colonization by Penicillium expansum

Small secreted molecules affect fungal biology

Fungal small secreted molecules modulate environmental pH and pathogenicity

GLA requirement for colonization and conidiation by P. expansum

pH and gene activation

pH and secondary metabolism of patulin production

The effect of acidification by GLA accumulation on patulin and pathogenicity of P. expansum

Modulating the activation of small secreted molecules.

11. Evolutionary Adaptation as a Tool to Generate Targeted Mutant Strains as Evidenced by Increased Inulinase Production in Aspergillus oryzae

Results and discussion

Index.

Notes:

Description based on print version record.

ISBN:

1-910190-40-3

OCLC:

949884671