Developmental and Stem Cell Biology in Health and Disease Ahmed El Hashash.

Format:

Book

Author/Creator:

El-Hashash, Ahmed, author.

Language:

English

Subjects (All):

Stem cells--Research.

Stem cells.

Physical Description:

1 online resource (261 pages) : illustrations (some color)

Edition:

1st ed.

Place of Publication:

Sharjah, United Arab Emirates : Bentham Science Publishers, 2016.

Summary:

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed by the work of Thomson in 1998 on the technique for extracting human embryonic stem cells. Since then, stem cell research has rapidly expanded as a therapeutic avenue for different diseases in humans. This book explains the basic developmental biology of stem cells including the development of stem cells during the implantation stage in utero to the regulation of stem cell division. Medical applications of stem cells in the therapy of diseases such as cancer, neurodegenerative diseases, and bone diseases are also explained in subsequent chapters. The book also explains the effect of parasitic cells on stem cell growth. Concepts in the book are explained in a simple clear manner, making this book an informative reference for non-experts, students and professionals in the field of biology and medicine.

Contents:

Intro

CONTENTS

PREFACE

List of Contributors

Stem Cells, Developmental Biology and Reparative/ Regenerative Medicine: Tools and Hope for Better Human Life

The First Morphogenetic Events During Mammalian Development

INTRODUCTION

1. MAMMALIAN PRE-IMPLANTATION DEVELOPMENT

Fertilization

Changes in Male Gamete

Changes in Female Gamete

Cleavage

2. MAMMALIAN DEVELOPMENT DURING IMPLANTATION

3. EARLY MAMMALIAN POST-IMPLANTATION DEVELOPMENT

Gastrulation

Formation of the Notochord

Establishment of the Body Axes

Changes of the Shape of the Embryonic Disc

Organogenesis

Embryonic Folding

Morphogenetic Changes of the Ectodermal Germ Layer

Morphogenetic Changes of the Mesodermal Germ Layer

Morphogenetic Changes of the Endodermal Germ Layer

EMBRYONIC STEM CELLS

Introduction

Embryonic Sources of Stem Cell Lines

Non-Embryonic Sources of Stem Cell Lines

Embryonic Stem Cell Generation and Fate

Clinical Application of Embryonic Stem Cells

CONFLICT OF INTEREST

ACKNOWLEDGEMENTS

REFERENCES

Gene and Signals Regulating Stem Cell Fates

THE HIERARCHY OF HEMATOPOIETIC CELLS

REGULATION OF HEMATOPOIESIS

CYTOKINES: A KEY REGULATOR OF HSCS

FUNCTIONS OF NOTCH PATHWAY IN HSCS

FUNCTIONS OF WNT SIGNALING PATHWAY IN THE SELF-RENEWAL OF HSCS

INTERACTION BETWEEN NOTCH AND WNT SIGNAL PATHWAYS IN HSC

FUNCTIONS OF SMAD SIGNALING PATHWAY

FUNCTIONAL ROLES OF ANGIOPOIETIN-LIKE PROTEINS IN HSCS

HSC NICHE

CLINICAL SIGNIFICANCES AND APPLICATIONS OF HSCS IN CELL AND GENE THERAPY

Stem Cell Biology: Flies As Models and Examples

BASICS OF STEM CELLS

NICHE REGULATION IN DROSOPHILA GERMLINE STEM CELLS

STEM CELL NICHE IN THE OVARIAN GERMLINE OF DROSOPHILA.

STEM CELLS WITHOUT A NICHE: DROSOPHILANEUROBLASTS

DEVELOPMENT OF NEUROBLASTS IN DROSOPHILA

PROGENITOR CELL NICHE IN DROSOPHILA HEMATOPOIETIC PRECURSOR CELLS

SITES OF TRANSIENT EMBRYONIC HEMATOPOIESIS

FUNCTIONS OF EXTRACELLULAR MATRIX AND CELL ADHESION PROTEINS IN NICHE MORPHOGENESIS CHARACTERISTICS

DOES IT DIFFER BETWEEN MALE AND FEMALE FLIES? DROSOPHILA

MODE OF DROSOPHILA STEM CELL DIVISION AND REGULATION OF CENTROSOME DYNAMICS

Behavior and Asymmetric Cell Divisions of Stem Cells

1. INTRODUCTION

2. SOURCES, BEHAVIOR AND CELLULAR PROPERTIES OF STEM CELLS

2.1. Stem Cell Sources

2.2. Behavior and Cellular Properties of Stem Cells: Cell Division, Cell Cycle, and Life Span

3. SYMMETRIC VERSUS ASYMMETRIC CELL DIVISION

Asymmetry Stem Cell Divisions in Different Systems

Drosophila Intestinal Stem Cells

HEMATOPOIETIC STEM CELLS (HSCS)

MUSCLE STEM CELLS

MAMMALIAN EPIDERMAL STEM/PROGENITOR CELLS

MAMMALIAN NEURAL STEM/PROGENITOR CELLS

LUNG EPITHELIAL STEM/PROGENITOR CELLS IN MAMMALS

CONCLUDING REMARKS AND FUTURE DIRECTIONS

Adult Stem Cell Niches and Their Regulatory Molecular Mechanisms

1. ADULT SC NICHES

Regulatory Mechanisms of Intrinsic Stem Cells

Role of Neighboring Stromal Cells

Functions of Extracellular Matrix and Physical Contact

Functions of Distal Signals from the Macro-Environment

2. MOLECULAR MECHANISMS CONTROLLING ADULT SC NICHES

Intrinsic Signals of Survival and Maintenance

Extrinsic Molecular Signals Regulating SC Quiescence and Self-Renewal.

Activating Signals Required for Tissue Repair and Regeneration

3. DYSFUNCTION OF SC NICHE

CONCLUDING REMARKS

Stem Cell Regulatory Mechanisms During Wound Healing and Cancer

STEM CELLS AND TISSUE INJURIES

Stem Cells and Cardiac Injuries

Stem Cells and Nervous System Damages

Stem Cells and Kidney Injury/Recovery

Stem Cells and Other Tissue Injuries

PARACRINE EFFECT OF STEM CELLS IN CANCER

Glioma

Kidney Cancer

Colon Cancer

Ovarian Cancer

Breast Cancer

Other Cancers

CONCLUSION

Stem Cells in Cancer Development and Therapy

MAY CANCER BE A DISEASE OF STEM CELLS?

DEVELOPMENT OF STEM CELLS

EFFECTS OF INFLAMMATORY REACTIONS ON STEM CELLS

THE DRIFT OF NORMAL STEM CELLS INTO CANCR STEM CELLS

CANCER STEM CELL HYPOTHESIS

A NEW THERAPEUTIC APPROACH

NANOTECHNOLOGY IN CANCER STEM CELL THERAPY

OPPORTUNITY FOR NOVEL THERAPEUTIC REGIMENS

Stem Cells and Neurodegenerative Diseases

2. ROLE OF STEM CELLS IN THE REGENERATIVE MEDICINE

2.1. Embryonic Stem Cells

2.1.1. Embryonic Germ Cells

2.1.2. Amniotic Epithelial Cells

2.1.3. Embryonic Stem Cells and Regenerative Medicine

2.2. Adult Stem Cells

2.2.1. Hematopoietic Stem Cells

2.2.2. Neural Stem Cells

2.2.3. Mesenchymal Stem Cells

2.2.4. Adult Stem Cells and Regenerative Medicine

3. STEM CELLS THERAPEUTIC STRATEGY FOR NEURO-DEGENERATIVE DISEASES

3.1. Alzheimer's Disease

3.2. Parkinson's Disease (PD)

4. FUTURE PROSPECTIVE

Stem Cells and Bone Disorders

2. BONE STRUCTURE

2.1. Bone Matrix.

2.2. Cellular Elements

2.3. Bone Remodeling

2.3.1. Mechanism of Bone Remodeling

3. OSTEOPOROSIS

3.1. Clinical Diagnosis of Osteoporosis

3.2. Current Therapy for Osteoporosis

3.2.1. Mechanisms Behind the Current Therapy for Osteoporosis

4. TOOTH ENGINEERING

4.1. Stem Cells Therapy and Dentine Regeneration

4.2. Dental Pulp Stem Cells and Aging

A Scope on Stem Cells and Human Parasites

1. MEDICAL PARASITOLOGY

WHAT DOES IT MEAN?

2. PARASITIC INFECTION: WOULD IT BE A HAZARD AFTER STEM CELL TRANSPLANTATION?

2.A. Relapse of a Dormant Infection

2.A.1. Cryptosporidiosis

2.A.2. Toxoplasmosis

2.B. Parasite Transmission Through Stem Cells Transplantation

2.B.1. Leishmaniasis

2.B.2. Malaria

3. STEM CELLS: WOULD THEY BE A POTENTIAL REPAIR IN PARASITIC INDUCED TISSUE DAMAGE?

3.A. Schistosomiasis

3.B. Malaria

3.C. Chagas Disease

4. PARASITIC STEM CELLS: CAN THEY BE THE TARGET OF ANTI-PARASITIC THERAPY?

4.A. Schistosomiasis

4.B. Alveolar Ecchinochoccosis

5. PARASITES: CAN THEY BE TRIGGERS FOR STEM CELL FACTOR PRODUCTION AND STEM CELL CULTURE?

SUBJECT INDEX.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed July 29, 2016).

ISBN:

9781681082196

1681082195

OCLC:

953844096