The pancreas : an integrated textbook of basic science, medicine, and surgery / edited by Hans G. Beger [and eight others].

Format:

Book

Contributor:

Beger, H. G. (Hans G.), editor.

Standardized Title:

Pancreas (Beger)

Language:

English

Subjects (All):

Pancreas--Diseases.

Pancreas.

Physical Description:

1 online resource (1,175 pages) : illustrations (some color)

Edition:

Third edition.

Place of Publication:

Hoboken, New Jersey : Wiley Blackwell, 2018.

Summary:

This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations. Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors. * The most encyclopedic book on the pancreas-providing outstanding and clear guidance for the practicing clinician * Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management * Completely updated with brand new chapters * Over 500 downloadable illustrations * An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.

Contents:

Intro

Title Page

Copyright Page

Contents

Contributors

Preface

Abbreviations

About the Companion Website

Section 1 Anatomy of the Pancreas

Chapter 1 Development of the Pancreas and Related Structures

Anatomy of the Pancreas

Organogenesis in the Region of the Pancreas

Early Pancreatic Development

Differentiation of Pancreas Cell Types

Transcriptional Mechanisms Underlying Pancreatic Cell Fate Decision

Development and Disease

Acknowledgment

References

Chapter 2 Anatomy, Histology, and Fine Structure of the Pancreas

Introduction

Gross Anatomy

Histology and Ultrastructure

Endocrine Pancreas

Acknowledgments

Chapter 3 Congenital and Inherited Anomalies of the Pancreas

Primary Malformations

Isolated Congenital Disorders of Pancreatic Endocrine Function

Other Hereditary Disorders with Variable Pancreatic Involvement and Metabolic Diseases Affecting the Pancreas

Inherited Metabolic Disorders Affecting the Pancreas

Section 2 Physiology and Pathophysiology of Pancreatic Functions

Chapter 4 Physiology of Acinar Cell Secretion

Composition of Pancreatic Acinar Juice

Acinar Fluid and Enzyme Secretion

Ca2+ Signaling

Organelles Important for Ca2+ Homeostasis

Mechanisms of Ca2+ Signal Generation

Ca2+ Entry and Exit

Ca2+-Mediated Control of Enzyme Secretion

Ca2+-Mediated Control of Fluid Secretion

Dangers of Ca2+ Signaling

Chapter 5 Physiology of Duct Cell Secretion

Sequential Secretion by Acinar and Duct Cells

Regulation of Ductal Secretion

The Ca2+ and cAMP Pathways Synergize to Activate Ductal Secretion

Ductal Secretion-Associated Pancreatic Diseases

Chapter 6 Pathophysiology of Experimental Pancreatitis.

Introduction

Models of Acute Pancreatitis

Phases of Acute Pancreatitis

Early Intra-Acinar Events in Acute Pancreatitis

Conclusion

Chapter 7 Physiology and Pathophysiology of Function of Sphincter of Oddi

Anatomy and Morphology

Innervation

Physiology

Motility of the Sphincter of Oddi

Sphincter of Oddi Motility Studies in Animals

Sphincter of Oddi Motility in Humans

Pathophysiology of the Sphincter of Oddi Dysfunction (SOD)

Chapter 8 Neurohormonal and Hormonal Control of Pancreatic Secretion

Stimulation of Pancreatic Secretion

Inhibition of Pancreatic Secretion

Feedback Regulation of Pancreatic Secretion

Chapter 9 Regulation of Pancreatic Protein Synthesis and Growth

Regulation of Protein Synthesis

Regulation of Pancreatic Growth

Chapter 10 Fibrogenesis in the Pancreas: The Role of Stellate Cells

Pancreatic Stellate Sells (PSC)

Acute Pancreatitis

Chronic Pancreatitis

Pancreatic Cancer

Chapter 11 Fibrogenesis of the Pancreas: The Role of Macrophages

Macrophages

Origin and Characteristics of Pancreatic Macrophages

Role of Macrophages in Chronic Pancreatitis-Associated Fibrosis

Role of Macrophages in Pancreatic Cancer-Associated Fibrosis

Chapter 12 Insulo-Acinar Relationship

Structural Relationships Between Pancreatic Islets and Exocrine Pancreas

Insulo-Acinar Portal System

Regulation of Pancreatic Exocrine Secretion by Islet Hormones

Pancreatic Exocrine Function and Diabetes Mellitus

Section 3 Acute Pancreatitis

Chapter 13 Epidemiology and Etiology of Alcohol‐Induced Pancreatitis

Introduction.

Epidemiology

Pathogenesis

Summary

Chapter 14 Epidemiology and Etiology of Acute Biliary Pancreatitis

Etiology of Gallstone Pancreatitis

Epidemiology of Biliary Acute Pancreatitis

Chapter 15 Genetic Factors in Acute Pancreatitis

Genetic Susceptibility Factors

Multiple Genetic Defects and Susceptibility

Progression to Chronic Pancreatitis

Future Directions

Chapter 16 The Role of the Intestine and Mesenteric Lymph in the Development of Systemic Inflammation and MODS in Severe Acute Pancreatitis

Role of the Intestine and Mesenteric Lymph in Multiple Organ Dysfunction Syndrome

Role of the Intestine in Severe Acute Pancreatitis

Altered Gut-Lymph Composition in Acute Pancreatitis

Gut-Lymph Toxicity in Acute Pancreatitis

Translating the Gut-Lymph Concept to Clinical Treatments for Acute Pancreatitis

Chapter 17 The Role of Neurogenic Inflammation in Pancreatitis

Chapter 18 Molecular, Biochemical, and Metabolic Abnormalities in Acute Pancreatitis

Molecular and Biochemical Abnormalities

Metabolic and Systemic Abnormalities

Electrocardiographic Abnormalities in Acute Pancreatitis

Chapter 19 Histopathology of Acute Pancreatitis

Definition

Histopathologic Patterns of Tissue Necrosis

Acute Pancreatitis with Type 1 Necrosis Pattern

Acute Pancreatitis with Type 2 Necrosis Pattern

Acute Pancreatitis with Type 3 Necrosis Pattern

Histopathology Related to Etiologic Factors and Pathophysiologic Mechanisms

Unsolved Questions

Chapter 20 Clinical Classification Systems of Acute Pancreatitis

Reasons for Classifying the Severity of Acute Pancreatitis.

New Classification Systems

Validation and Comparison of Classification Systems

Future of Classification Systems

Conclusions

Chapter 21 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis

Historical Perspectives: Approaches to Severity Assessment

Dynamics of Organ Failure

Multiparameter Scoring Systems

Laboratory Variables

Overview

Chapter 22 Acute Pancreatitis Associated With Congenital Anomalies

Pancreas Divisum

Anomalous Pancreaticobiliary Ductal Union

Choledochal Cyst/Choledochocele

Annular Pancreas

Ectopic Pancreatic Tissue

Enteric Duplication Cysts

Chapter 23 Acute Pancreatitis in Children

Incidence

Etiology

Pathophysiology

Investigations

Diagnosis

Imaging

Management

Outcomes

Acute Recurrent Pancreatitis

Chapter 24 Acute Pancreatitis Associated With Metabolic Disorders, Infectious Diseases, or Drugs

Metabolic Diseases

Infectious Diseases

Drug-Related Diseases

Chapter 25 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis

Classification of Acute Pancreatitis

Radiographic Diagnosis of Severe Acute Pancreatitis

Diagnosis of Local Complications of Acute Pancreatitis

Radiologic Staging of Severe Acute Pancreatitis

Limitations and Pitfalls of Radiological Diagnosis of Acute Pancreatitis

Clinical Course and Medical Treatment of Acute Pancreatitis

Chapter 26 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition

Fluid Resuscitation

Enteral and Parenteral Nutrition

Chapter 27 ICU Treatment of Severe Acute Pancreatitis.

Pre‐ICU Management

Special Considerations

Indications for ICU Admission

ICU Treatment of Severe Acute Pancreatitis

Early ICU Management (0-48 Hours from Onset of Pain)

Management of Metabolic Derangements

Late ICU Management (&gt

48 Hours After the Onset of Pain)

Management of Infectious Risks

Transition Planning

Chapter 28 Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations

Infectious Complications

Spectrum of Bacteria

Rationales for Antibiotics in Acute Pancreatitis

Clinical Studies with Antibiotics

Indications for Antibiotic Treatment

Limitations of Antibiotic Treatment

Interventional and Surgical Management of Acute Pancreatitis

Chapter 29 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis

Interventions for Pancreatic Necrosis: Historical Perspective

Indications and Timing of Intervention

Pancreatic Necrosis with Infection

Symptomatic Pancreatic Necrosis/Walled-Off Necrosis

Surgical and Interventional Procedures

Surgical Debridement

Percutaneous Catheter Drainage

Direct Endoscopic Necrosectomy

Chapter 30 Management of Infected Pancreatic Necroses: An Endoscopic Approach

Pancreatic Necrosis

Mechanical Intervention

Transmural Drainage

Results of Endoscopic Therapy of Pancreatic Necrosis

Adverse Events of Endoscopic Therapy of Pancreatic Necrosis

Chapter 31 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis

Technique

Techniques for Complex Collections

Early Complications

Postoperative Course

Outcome

Chapter 32 Open Surgical Debridement in Necrotizing Pancreatitis

General Technique of Open Surgical Debridement.

Continuous Closed Lavage.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781119188414

1119188415

9781119188407

1119188407

9781119188421

1119188423

OCLC:

1019661256