3D and 4D printing in biomedical applications : process engineering and additive manufacturing / edited by Mohammed Maniruzzaman.

Format:

Book

Author/Creator:

Mohammed Maniruzzaman, author.

Series:

THEi Wiley ebooks.

THEi Wiley ebooks

Language:

German

Subjects (All):

Three-dimensional printing.

Biomedical engineering.

Physical Description:

1 online resource (493 pages)

Edition:

1st ed.

Place of Publication:

Weinheim, Germany : Wiley-VCH, [2019]

System Details:

Access using campus network via VPN at home (THEi Users Only).

Summary:

A professional guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields 3D and 4D Printing in Biomedical Applications offers an authoritative guide to 3D and 4D printing technology in the biomedical and pharmaceutical arenas. With contributions from an international panel of academic scholars and industry experts, this book contains an overview of the topic and the most current research and innovations in pharmaceutical and biomedical applications. This important volume explores the process optimization, innovation process, engineering, and platform technology behind printed medicine. In addition, information on biomedical developments include topics such as on shape memory polymers, 4D bio-fabrications and bone printing. The book covers a wealth of relevant topics including information on the potential of 3D printing for pharmaceutical drug delivery, examines a new fabrication process, bio-scaffolding, and reviews the most current trends and challenges in biofabrication for 3D and 4D bioprinting. This vital resource: -Offers a comprehensive guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields -Includes information on the first 3D printing platform to get FDA approval for a pharmaceutical product -Contains a review of the current 3D printed pharmaceutical products -Presents recent advances of novel materials for 3D/4D printing and biomedical applications Written for pharmaceutical chemists, medicinal chemists, biotechnologists, pharma engineers, 3D and 4D Printing in Biomedical Applications explores the key aspects of the printing of medical and pharmaceutical products and the challenges and advances associated with their development.

Contents:

Cover

Title Page

Copyright

Contents

Preface

Chapter 1 3D/4D Printing in Additive Manufacturing: Process Engineering and Novel Excipients

1.1 Introduction

1.2 The Process of 3D and 4D Printing Technology

1.3 3D/4D Printing for Biomedical Applications

1.4 Smart or Responsive Materials for 4D Biomedical Printing

1.5 Classification of 3D and 4D Printing Technologies

1.5.1 Fused Filament Fabrication (FFF) - Extrusion‐Based Systems

1.5.2 Powder Bed Printing (PBP) - Droplet‐Based Systems

1.5.3 Stereolithographic (SLA) Printing - Resin‐Based Systems

1.5.4 Selective Laser Sintering (SLS) Printing - Laser‐Based Systems

1.6 Conclusions and Perspectives

References

Chapter 2 3D and 4D Printing Technologies: Innovative Process Engineering and Smart Additive Manufacturing

2.1 Introduction

2.2 Types of 3D Printing Technologies

2.2.1 Stereolithographic 3D Printing (SLA)

2.2.2 Powder‐Based 3D Printing

2.2.3 Selective Laser Sintering (SLS)

2.2.4 Fused Deposition Modeling (FDM)

2.2.5 Semisolid Extrusion (EXT) 3D Printing

2.2.6 Thermal Inkjet Printing

2.3 FDM 3D Printing Technology

2.3.1 FDM 3D Printing Applications in Unit Dose Fabrications and Medical Implants

2.4 Hot Melt Extrusion Technique to Produce 3D Printing Polymeric Filaments

2.5 Smart Medical Implants Integrated with Sensors

2.5.1 Examples of Medical Implants with Sensors

2.6 4D Printing and Future Perspectives

2.6.1 4D Printing and Its Transition in Material Fabrication

2.6.2 Shape Memory or Stimuli‐Responsive Mechanism of 4D Printing

2.6.3 Factors Affecting 4D Printing

2.6.3.1 Humidity‐Responsive Materials

2.6.3.2 Temperatures

2.6.3.3 Electronic and Magnetic Stimuli

2.6.3.4 Light

2.6.4 Future Perspectives of 4D Printing

2.7 Regulatory Aspects

2.8 Conclusions

References.

Chapter 3 3D Printing: A Case of ZipDose® Technology - World's First 3D Printing Platform to Obtain FDA Approval for a Pharmaceutical Product

3.1 Introduction

3.2 Terminology

3.3 Historical Context for This Form of 3D Printing

3.4 ZipDose® Technology

3.5 3D Printing Machines and Pharmaceutical Process Design

3.5.1 Overview

3.5.2 Generalized Process in the Pharmaceutical Context

3.5.3 Exemplary 3DP Machine Designs

3.6 Development of SPRITAM®

3.6.1 Product Concept and Need

3.6.2 Regulatory Approach

3.6.3 Introduction of the Technology to FDA

3.6.4 Target Product Profile

3.6.5 Synopsis of Formulation and Clinical Development

3.7 Conclusion

Acknowledgments

Chapter 4 Manufacturing of Biomaterials via a 3D Printing Platform

4.1 Additive Manufacturing and Bioprinting

4.2 Bioinks

4.2.1 Printability Control - Bioink Composition and Environmental Factors

4.2.2 Mechanisms for Filament Formation and Stability

4.3 3D Bioprinting Systems

4.3.1 Multifaceted Systems

4.3.2 Major Components

4.3.3 Pneumatic Printhead

4.3.4 Mechanical Displacement Printhead

4.3.5 Inkjet Printhead

4.3.6 Heated and Cooled Printheads

4.3.7 High‐Temperature Extruder

4.3.8 Multimaterial Printhead

4.3.9 Heated and Cooled Printbed

4.3.10 Clean Chamber Technology

4.3.11 Video‐Capture Printhead and Sensors

4.3.12 Integrated Intelligence

4.4 Applications

4.4.1 Internal Architecture

4.4.2 Integrated Vascular Networks and Microstructure Patterning

4.4.3 Personalized Medicine

4.5 Steps Necessary for Broader Application

Chapter 5 Bioscaffolding: A New Innovative Fabrication Process

5.1 Introduction: From Bioscaffolding to Bioprinting

5.2 Scaffolding

5.2.1 Properties of Scaffolds.

5.2.2 Bioprinters vs Common 3D Printers: Approaches for Extrusion of Polymers

5.2.3 Comparing Cell Seeding Techniques to 3D Bioprinting or Cell‐Laden Hydrogels

5.2.3.1 From Printing to Bioprinting

5.2.3.2 Approaches of Stabilizing Printed Constructs

5.2.4 Examples/Applications of Cell‐Seeded Scaffolds

5.2.5 Data Processing of 3D CAD Data for Bioscaffolds

5.3 Bioprinted Scaffolds

5.3.1 Bioinks

5.3.2 Tools for Multimaterial Printing

5.3.3 Multimaterial Scaffold

5.3.4 Core-Shell Scaffolds

5.3.5 Additional Technical Equipment

5.3.6 Piezoelectric Pipetting Technology

5.3.7 Usage of Piezoelectric Inkjet Technology with Bioscaffolds

5.4 Applications of Bioscaffolder and Bioprinting Systems

5.4.1 Individualized Implants and Tissue Constructs

5.4.2 Green Bioprinting

5.4.3 Challenges for Clinical Applications of Bioprinted Scaffolds in Tissue and Organ Engineering

5.4.4 4D Printing

5.5 Conclusion

Chapter 6 Potential of 3D Printing in Pharmaceutical Drug Delivery and Manufacturing

6.1 Introduction

6.2 Pharmaceutical Drug Delivery

6.3 Conventional Manufacturing vs 3D Printing

6.4 Advanced Applications for Improved Drug Delivery

6.5 Instrumentations

6.6 Location of 3D Printing Manufacturing

6.6.1 Pharmaceutical Industry

6.6.2 At the Point of Care

6.6.3 Print‐at‐Home

6.7 Regulatory Aspects

6.8 Summary

Chapter 7 Emerging 3D Printing Technologies to Develop Novel Pharmaceutical Formulations

7.1 Introduction

7.2 FDM 3D Printing

7.3 Pressure‐Assisted Microsyringe

7.4 SLA 3D Printing

7.5 Powder Bed 3D Printing

7.6 SLS 3D Printing

7.7 3D Inkjet Printing

7.8 Conclusions

Chapter 8 Modulating Drug Release from 3D Printed Pharmaceutical Products

8.1 Introduction.

8.2 Pharmaceutically Used 3D Printing Processes and Techniques

8.2.1 Process Flow of 3D Printing Processes

8.2.2 Inkjet‐Based Printing Technologies

8.2.3 Extrusion‐Based Printing Techniques

8.2.4 Laser‐Based Techniques

8.3 Modifying the Drug Release Profile from 3D Printed Dosage Forms

8.3.1 Approaches to Modify the Drug Release

8.3.2 Modifying the Drug Release by Formulation Variation

8.3.2.1 Fused Filament Fabrication

8.3.2.2 Other Printing Techniques

8.3.3 Manipulating the Dosage Form Geometry as a Means to Modify API Release

8.3.3.1 Fused Filament Fabrication

8.3.3.2 Drop‐on‐Drop Printing

8.3.4 Dissolution Control via Directed Diffusion and Compartmentalization

8.3.4.1 Drop‐on‐Powder Printing

8.3.4.2 Fused Filament Fabrication

8.3.4.3 Printing with Pressure‐Assisted Microsyringes

8.4 Conclusion

Chapter 9 Novel Excipients and Materials Used in FDM 3D Printing of Pharmaceutical Dosage Forms

9.1 Introduction

9.2 Biodegradable Polyester

9.2.1 Polylactic Acid (PLA)

9.2.2 Poly( ‐caprolactone) (PCL)

9.3 Polyvinyl Polymer

9.3.1 Polyvinyl Alcohol (PVA)

9.3.2 Ethylene Vinyl Acetate (EVA)

9.3.3 Polyvinylpyrrolidone (PVP)

9.3.4 Soluplus

9.4 Cellulosic Polymers

9.4.1 Hydroxypropyl Cellulose (HPC)

9.4.2 Hydroxypropyl Methylcellulose (HPMC)

9.4.3 Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS)

9.5 Polymethacrylate‐Based Polymers

9.5.1 Eudragit RL/RS

9.5.2 Eudragit L100‐55

9.5.3 Eudragit E 100

9.6 Conclusion

Chapter 10 Recent Advances of Novel Materials for 3D/4D Printing in Biomedical Applications

10.1 Introduction

10.2 Materials for 3DP

10.3 Rheology

10.4 Ceramics for 3D Printing

10.5 Polymers and Biopolymers for 3D Printing

10.5.1 Polylactide (PLA)

10.5.2 Poly( ‐caprolactone) (PCL).

10.5.3 Hyaluronic Acid

10.6 4D Printing

10.6.1 Bioprinting

10.6.2 Smart or Intelligent Materials

10.6.2.1 Thermal Stimuli‐Induced Transformation

10.6.2.2 Hydrogel

10.7 3D and 4D Printed Bone Scaffolds with Novel Materials

10.7.1 3DP/4DP for Drug Delivery and Bioprinting

10.7.2 Polyurethane‐Based Scaffolds for Tissue Engineering

10.8 Future and Prospects

Chapter 11 Personalized Polypills Produced by Fused Deposition Modeling 3D Printing

11.1 Introduction

11.2 Polypharmacy and Polypills

11.2.1 Clinical Evidence and Current State of the Art

11.2.2 Future Personalization

11.3 FDM 3D Printing of Pharmaceutical Solid Dosage Forms

11.3.1 Basic Principle of FDM 3D Printing

11.3.2 Printing Parameter Control

11.3.3 Drug‐Loading Methods

11.4 Key Challenges in the Development of FDM 3D Printed Personalized Polypills

11.4.1 Printable Pharmaceutical Materials

11.4.2 Printing Precision and Printer Redesign

11.4.3 Regulatory Barriers for Personalized Polypill Printing

11.5 Conclusions and Future Remarks

Chapter 12 3D Printing of Metallic Cellular Scaffolds for Bone Implants

12.1 Introduction

12.2 Metal 3D Printing Techniques for Bone Implants

12.2.1 Selective Laser Melting

12.2.2 Selective Electron Beam Melting

12.3 Biometals for Bone Implants

12.3.1 Nondegradable Biometals

12.3.2 Biodegradable Biometals

12.3.3 3D Printing of Biometals

12.3.3.1 Ti-6Al-4V ELI Alloy

12.3.3.2 CoCrMo Alloy

12.3.3.3 Stainless Steel 316L Alloy

12.3.3.4 NiTi Shape Memory Alloy

12.3.3.5 Tantalum

12.3.3.6 Mg and Its Alloy

12.4 Cellular Structure Design

12.4.1 Stochastic and Reticulated Cellular Design

12.4.2 Bend‐ and Stretch‐Dominated Cellular Design

12.4.3 Scaffold Design Feasibility

12.5 Outlook

Chapter 13 3D and 4D Scaffold‐Free Bioprinting.

Notes:

Description based on print version record.

ISBN:

9783527813674

3527813675

9783527813698

3527813691

9783527813704

3527813705

OCLC:

1078996045