Enteroviruses : omics, molecular biology, and control / edited by William T. Jackson, Carolyn B. Coyne.

Format:

Book

Contributor:

Jackson, William T., 1971- editor.

Coyne, Carolyn B., editor.

Language:

English

Subjects (All):

Enteroviruses.

Physical Description:

1 online resource (164 pages)

Edition:

1st ed.

Place of Publication:

Norfolk, UK : Caister Academic Press, [2018]

Summary:

This book represents a comprehensive tour of the current most important enterovirus research. The editors, Dr. Jackson and Dr. Coyne, have assembled a group of enteroviral experts who cover topics including viral entry and the hijacking of host functions; the dynamic analysis of ever-evolving virus genomes; the cellular membrane changes promoting virus assembly and release. This volume is a must-read for anyone with an interest in this family of viruses and an important acquisition for all microbiology libraries.

Contents:

Intro

Contents

Current Books of Interest

Preface

1 Enteroviruses Future

Introduction

Curiouser and curiouser

Viral eradication and control by vaccination

Antivirals: crucial for post eradication of poliovirus and needed for all Enteroviruses

Enteroviruses in 10 years

2 Enterovirus Receptors and Entry

The Enterovirus capsid

Attachment to a cellular receptor

Use of multiple receptors

Uncoating: formation of expanded A-particles

Uncoating: RNA release

Where does uncoating occur?

Introduction to endocytosis

Other forms of endocytosis

Post-internalization events

Concluding thoughts

3 Hijacking Host Functions for Translation and RNA Replication by Enteroviruses

Viral proteinase disruption of host machinery

Use and abuse of host cell functions for viral translation and RNA replication

Evasion of host antiviral and stress response pathways and mRNA surveillance

Summary

4 The Omics of Rhinoviruses

The Rhinoviruses

How RV taxa are defined

Making an informative alignment

Prediction of an RV-C capsid

Statistical prediction of immunogenicity

Other uses for RV sequences

5 Viral Population Dynamics and Sequence Space

Quasispecies dynamics of Enteroviruses: model RNA viruses

Mutation rates and RdRp fidelity

Recombination

Sequence space and fitness landscapes

Viral adaptation dynamics: step-wise walks along the landscape

Intra-population interactions: complementation and interference

Group contribution of minority variants to phenotype

The genomics era: challenges and prospects of high-throughput sequencing technologies

Final conclusions

6 Enterovirus Control of Cytoplasmic RNA Granules

Cytoplasmic RNA granules

Mechanisms of stress granule assembly.

Enterovirus relationships with stress granules: antagonism rules

How does G3BP cleavage block stress granule assembly?

Enterovirus relationships with P-bodies: rapid destruction

Why Enteroviruses must antagonize RNA granules

Future directions

7 The Autophagic Pathway and Enterovirus Infection

Autophagy was first identified in Enterovirus infections through electron microscopy

Basics of autophagy

The relationship between Enteroviruses and autophagy

Release of Enteroviruses without lysis

Enterovirus proteins promote autophagic signalling and degradation

Triggering of autophagy upon virus entry

Coxsackievirus regulation of the autophagy pathway

Enterovirus 71

Rhinovirus

The dual nature of autophagy

The current model

8 The Lipid Blueprints of Replicating Viral Genomes

Membranes facilitate replication

Convergence on a common lipid blueprint

Advantages of enriching for PI4P lipids in replication organelles

Mechanisms and consequences of viral induction of PI4P lipid production

Phosphatidylethanolamine

Cholesterol: co-factor to stabilize PI4P and phosphatidylethanolamine domains

Viral mechanisms of obtaining cholesterol

Therapeutic potential of targeting lipids and future directions

Index.

Notes:

Description based on print version record.

ISBN:

1-910190-74-8

OCLC:

1049975168