Wound healing, tissue repair, and regeneration in diabetes edited by Debasis Bagchi, Amitava Das, and Sashwati Roy

Format:

Book

Contributor:

Bagchi, Debasis

Das, Amitava

Roy, Sashwati

Language:

English

Subjects (All):

Diabetes.

Wound healing.

Diabetes Mellitus.

Wound Healing.

Medical Subjects:

Diabetes Mellitus.

Wound Healing.

Physical Description:

1 online resource

Place of Publication:

[S.l.] ELSEVIER ACADEMIC PRESS 2020

Summary:

Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals

Contents:

References

Chapter 2: Role of oxidants and antioxidants in diabetic wound healing

1. Introduction

2. Oxidative stress and wound healing

3. Antioxidants and wound healing

3.1. Examples of enzymatic antioxidants

3.1.1. SOD, GSTs, GPx, NADPH

3.1.2. Heme-oxygenase 1 (HO-1)

3.1.3. Peroxiredoxins and thioredoxins

3.2. Nonenzymatic antioxidants

3.2.1. Vitamin C

3.2.2. Vitamin E

3.2.3. Vitamin D

3.2.4. Alpha-lipoic acid (-LA) and its reduced form of dihydrolipoic acid (DHLA)

3.2.5. N-acetyl-cysteine (NAC)

3.3. Other small molecules

3.4. Herbal extracts

Front Cover

Wound Healing, Tissue Repair, and Regeneration in Diabetes

Copyright

Dedication

Contents

Contributors

About the authors

Preface

Part 1: Background and overview

Chapter 1: The diabetic foot

2. Clinical classification

2.1. Definition

2.2. Risk factors

2.3. Etiology

2.4. Epidemiology

3. The complicated diabetic foot

3.1. Vascular

3.2. Neural

3.3. Skin and soft tissue

3.4. Bone

3.5. Infection

4. Care and management

4.1. Treatment

4.1.1. Other factors

4.2. Prevention

5. Conclusion

3.4.1. Curcumin

3.4.2. Honey

3.5. Factor-E2-related factor (Nrf2)

4. Diabetes, oxidative stress, and impaired/chronic wounds

5. OS and the triggering of wound chronicity

6. Conclusions

References

Further reading

Chapter 3: Chronic infection and inflammation: Hallmarks of diabetic foot ulcers

1. Background

2. Chronicity of wound infection

2.1. Antibiotic resistance (ABR)

2.2. Biofilm infection

2.3. Novel approaches for therapeutics

2.3.1. Electroceuticals

2.3.2. Bacteriophage

3. Dysregulated resolution of wound inflammation

3.1. miRNA

3.2. Macrophage function and phenotypes

3.3. Efferocytosis

4. Conclusion

Chapter 4: Diabetic peripheral neuropathy: An insight into the pathophysiology, diagnosis, and therapeutics

2. Neuropathy

2.1. Peripheral neuropathy

2.2. Cranial neuropathy

2.3. Autonomic neuropathy

2.4. Focal neuropathy

2.4.1. Mononeuropathy

2.4.2. Polyneuropathy

3. Experimental mouse models for DPN

3.1. Diet-induced DPN mouse model

3.2. Chemically induced DPN mouse model

3.3. Genetically modified DPN mouse model

4. Nociception assays

4.1. Mechanical stimuli

4.1.1. The manual von Frey test

4.1.2. The electronic von Frey

4.1.3. Randall-Selitto test

4.2. Heat stimuli

4.2.1. The tail-flick test

4.2.2. Hot plate test

4.2.3. Hargreaves test

4.2.4. Thermal probe test

4.3. Cold stimuli

4.3.1. Cold plate test

4.3.2. Acetone evaporation test

4.3.3. Cold plantar assay

4.3.4. Temperature preference test

5. Nonstimulus evoked nociception

5.1. Grimace scales

5.2. Burrowing

5.3. Weight-bearing and gait analysis

5.4. Automated behavioral analysis

Notes:

Includes bibliographical references and index

Other Format:

Print version:

ISBN:

9780128164143

012816414X

OCLC:

1151483670

Access Restriction:

Restricted for use by site license