Mendelian randomization : methods for using genetic variants in causal estimation / Stephen Burgess, Simon G. Thompson.

Format:

Book

Author/Creator:

Burgess, Stephen, author.

Thompson, Simon G., author.

Series:

Interdisciplinary statistics.

Chapman and Hall/CRC Interdisciplinary Statistics

Language:

English

Subjects (All):

Medical genetics--Statistical methods.

Medical genetics.

Physical Description:

1 online resource (222 p.)

Edition:

1st edition

Place of Publication:

[Boca Raton] : [CRC Press], [2015]

Language Note:

English

System Details:

text file

Summary:

Mendelian randomization is a way of assessing causal associations from observational data, which is especially important for medical scientists and epidemiologists who want to know the true causes of diseases. Covering this emerging area of research in biostatistics and epidemiology, this book examines the use of genetic variants as instrumental variables to assess causal associations. It also discusses statistical issues with instrumental variable analysis and explores practical applications of Mendelian randomization. The methods are illustrated with a variety of detailed worked examples usi

Contents:

Front Cover; Contents; Preface; Abbreviations; Notation; Part I: Using genetic variants as instrumental variables to assess causal relationships; Chapter 1: Introduction and motivation; Chapter 2: What is Mendelian randomization?; Chapter 3: Assumptions for causal inference; Chapter 4: Methods for instrumental variable analysis; Chapter 5: Examples of Mendelian randomization analysis; Chapter 6: Generalizability of estimates from Mendelian randomization; Part II: Statistical issues in instrumental variable analysis and Mendelian randomization

Chapter 7: Weak instruments and finite-sample biasChapter 8: Multiple instruments and power; Chapter 9: Multiple studies and evidence synthesis; Chapter 10: Example: The CRP CHD Genetics Collaboration; Part III: Prospects for Mendelian randomization; Chapter 11: Future directions; Bibliography; Back Cover

Notes:

Description based upon print version of record.

Includes bibliographical references.

Description based on online resource; title from PDF title page (ebrary, viewed February 27, 2015).

ISBN:

0-429-19022-0

1-4665-7318-X

9780429190223

OCLC:

905859603