The IPN regulates anxiety independently of drug addiction / Ian McLaughlin.

Format:

Book

Thesis/Dissertation

Author/Creator:

McLaughlin, Ian, author.

Contributor:

University of Pennsylvania. Department of Neuroscience, degree granting institution.

De Biasi, Mariella, degree supervisor.

Language:

English

Subjects (All):

Neurosciences.

Neuroscience--Penn dissertations.

Penn dissertations--Neuroscience.

Local Subjects:

Neurosciences.

Neuroscience--Penn dissertations.

Penn dissertations--Neuroscience.

Genre:

Academic theses.

Physical Description:

1 online resource (355 pages)

Contained In:

Dissertations Abstracts International 81-08B.

Place of Publication:

[Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2019.

Language Note:

English

System Details:

Mode of access: World Wide Web.

text file

Summary:

This work is devoted to better understanding how a component of one of the principle anatomical intersections of cognitive, emotional, and motivational signaling regulates anxiety and addiction. The majority of my work focused on the interpeduncular nucleus (IPN). The IPN and its principle source of afferent signals, the medial habenula (MHb), comprise a junction of signaling within the diencephalic conduction system (DDC). Along with the medial forebrain bundle, the DDC is a highly conserved pathway by which signals from the limbic forebrain reach the midbrain and hindbrain. Work in our lab and others has implicated the MHb-IPN axis in the aversive affective and somatic withdrawal syndrome that manifests following cessation of chronic exposure to habit-forming drugs, including alcohol, nicotine, and opioids. Given that functional role, I sought to establish if this pathway regulates affect independently of chronic drug exposure. In addition to my primary work, additional experiments I performed contributed to the growing understanding of how this pathway functions within the context of addiction. In particular, I contributed to studies focused on how the presence of the α5 nicotinic acetylcholine receptor subunit (nAChRs) in the IPN and its neighboring structure, the ventral tegmental area (VTA), influences predispositions to alcohol and nicotine addictions in animal models. Using in vivo chemogenetics, viral tracing and receptor subunit rescue, microdialysis, and behavioral analyses, I worked to evaluate how perturbations of signaling within the IPN or VTA affected mouse behavior.Overall, I have found that the IPN does indeed regulate affect independently of chronic drug exposure, and that signaling via the α5 nAChR subunit within both the IPN and VTA significantly regulates drug-taking behavior.

Notes:

Source: Dissertations Abstracts International, Volume: 81-08, Section: B.

Advisors: De Biasi, Mariella; Committee members: Seema Bhatnagar; Julie Blendy; Irwin Lucki; Rebecca Ashare.

Department: Neuroscience.

Ph.D. University of Pennsylvania 2019.

Local Notes:

School code: 0175

ISBN:

9781392543443

Access Restriction:

Restricted for use by site license.

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