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Roles of VEGFC and VEGFR3 in lymphangiogenesis and angiogenesis / Lillian Y. Lim.
- Format:
- Book
- Thesis/Dissertation
- Author/Creator:
- Lim, Lillian Y., author.
- Language:
- English
- Subjects (All):
- Molecular biology.
- Cellular biology.
- Biology.
- Biochemistry.
- Cell and molecular biology--Penn dissertations.
- Penn dissertations--Cell and molecular biology.
- Local Subjects:
- Molecular biology.
- Cellular biology.
- Biology.
- Biochemistry.
- Cell and molecular biology--Penn dissertations.
- Penn dissertations--Cell and molecular biology.
- Genre:
- Academic theses.
- Physical Description:
- 1 online resource (135 pages)
- Contained In:
- Dissertations Abstracts International 81-08B.
- Place of Publication:
- [Philadelphia, Pennsylvania] : University of Pennsylvania ; Ann Arbor : ProQuest Dissertations & Theses, 2019.
- Language Note:
- English
- System Details:
- Mode of access: World Wide Web.
- text file
- Summary:
- The lymphatic system is a vascular system that is present throughout most organs of the body, and plays important roles in fluid homeostasis, lipid uptake in the intestines, as well as in immune cell trafficking and adipose metabolism. Vascular endothelial growth factor C (VEGFC) is the primary lymphangiogenic factor that stimulates lymphangiogenesis during development, signaling via its receptor vascular endothelial growth factor receptor 3 (VEGFR3). In the adult animal, lymphatic vessels are mostly quiescent, but wound healing that follows injury is often accompanied by lymphangiogenesis. The hemostatic response following injury brings platelets to the injury site that helps to stem bleeding, and subsequent fibrin clot formation helps to stabilize the clot. Here, using a novel tail injury assay, we showed that the hemostatic response mediates wound healing lymphangiogenesis by bringing VEGFC to the site of injury via platelets, and that thrombin, a serine protease present in injury sites, can cleave and activate VEGFC, elucidating novel roles for the hemostatic response in lymphangiogenesis. Together, these studies define a link between hemostasis and lymphangiogenesis, and reveal VEGFC to be the major lymphangiogenic factor in two different injury models.
- Notes:
- Source: Dissertations Abstracts International, Volume: 81-08, Section: B.
- Advisors: Kahn, Mark L; Committee members: Edward Morrisey; Nancy Speck; Sandra Ryeom; Stephen DiNardo.
- Department: Cell and Molecular Biology.
- Ph.D. University of Pennsylvania 2019.
- Local Notes:
- School code: 0175
- ISBN:
- 9781392891292
- Access Restriction:
- Restricted for use by site license.
- This item is not available from ProQuest Dissertations & Theses.
- This item must not be sold to any third party vendors.
- This item must not be added to any third party search indexes.
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