Endometrial Gene Expression : An Emerging Paradigm for Reproductive Disorders / edited by Joanne Kwak-Kim.

Format:

Book

Contributor:

Kwak-Kim, Joanne, editor.

SpringerLink (Online service)

Series:

Medicine (Springer-11650)

Language:

English

Subjects (All):

Reproductive health.

Gynecology.

Gene expression.

Reproductive Medicine.

Gene Expression.

Local Subjects:

Reproductive Medicine.

Gynecology.

Gene Expression.

Physical Description:

1 online resource (XIII, 220 pages) : 15 illustrations in color

Edition:

First edition 2020.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2020.

System Details:

text file PDF

Summary:

The endometrium goes through cyclical changes under the influence of hormones, and immune effectors in the endometrium change their populations cyclically as well. Dynamic changes in immune effectors determine endometrial cytokine and chemokine milieus and, consequently, the endometrial immune response. Endometrial immune responses have been shown to be important for trophoblast invasion and early pregnancy. Indeed, dysregulated endometrial inflammatory immune responses are associated with reproductive failures, such as recurrent pregnancy losses, repeated implantation failure, and gynecological diseases with oncogenic potential. Hence, the investigation of endometrial gene expression may predict infertility, gynecological and oncological conditions. This book presents the state of the art in endometrial gene expression as well as recent developmental findings relating to reproduction and reproductive disorders. It begins with a review of the genetic regulation of urogenital tract formation and molecular mechanism underlying the physiology of menstrual cycle before moving on to the current and emerging technological advances in molecular biology. Endometrial gene expressions of immune inflammatory conditions, viral infection, metabolic and nutritional conditions, and reproductive disorders are then presented in following chapters. Examples of the use and interpretation of gene expression in clinical scenarios including recurrent pregnancy losses, infertility and multiple implantation failures are presented with currently available endometrial gene analysis. Utilizing the latest evidence and clinical guidelines, Endometrial Gene Expression will be a cutting-edge resource for gynecologist, reproductive immunologist, reproductive endocrinologists, obstetrician, maternal fetal medicine specialist and other health care providers in the field of reproductive medicine. .

Contents:

Endometrial Development and Its Fine Structure

Molecular Biology Techniques for Endometrial Gene Expression: Recent Technological Advances

T Cell-related Endometrial Gene Expression Abnormalities

Role of Immunoregulatory Cytokine IL-15 in the Endometrium

Endometrial Gene Expression in Women with Repeated Implantation Failure

Endometrial Receptivity by ERA for Infertility

Endometrium Gene Expression and Epigenetic Regulation in Reproductive Failure

Endometrial Gene Expression for HHV6

Infection and Endometrial Gene Expression: HHV6 and Infertility

Endometrial Immune Inflammatory Gene Signature in Endometriosis

Gene Expression in Endometriosis

MicroRNA and Endometriosis

Metabolic and Nutritional Impact on Endometrial Gene Expression and Reproductive Disorders.

Other Format:

Printed edition:

ISBN:

978-3-030-28584-5

9783030285845

Access Restriction:

Restricted for use by site license.