Alphaviruses : current biology / edited by Suresh Mahalingam, Lara J. Herrero, Insitute of Glycomics, Griffith University, Gold Coast, QLD, Australia, and Belinda L. Herring, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia.

Format:

Book

Contributor:

Herring, Belinda L., editor.

Herrero, Lara J., editor.

Mahalingam, Suresh, editor.

Language:

English

Subjects (All):

Togaviruses.

Physical Description:

1 online resource (vii, 183 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Norfolk, England : Caister Academic Press, [2016]

Language Note:

English

Summary:

This timely book provides a comprehensive overview of the latest developments in alphavirus research. Written by a team of prominent scientists the main focus is on the pathogenesis and host interactions. Topics covered include: genome structure and replication; viral evolution; laboratory diagnosis and detection; interaction with the interferon system; antiviral responses in mosquitoes; animal models of alphavirus-induced inflammatory disease; clinical manifestations of arthritogenic alphaviruses; encephalitic alphaviruses; the application of alphavirus vectors for gene therapy; and chikungunya virus pathogenesis and the development of control strategies. As the first to focus exclusively on alphaviruses, this book serves as an invaluable resource for researchers and clinicians working with alphaviruses and related viruses. Essential reading.

Contents:

Intro

Contents

Current Books of Interest

Contributors

Preface

1: Alphavirus Genome Structure and Replication

Alphavirus structure and genomic organization

Alphavirus replication

2: Alphavirus Evolution

Phylogenetic relationships of alphaviruses

Microscale evolution

Consequences of alphavirus evolution

Conclusion

3: Laboratory Diagnosis and Detection of Alphaviruses

Introduction

Detection and diagnosis

Conclusions

4: The Interaction of Alphaviruses with the Interferon System

The role of IFN-α/β in control of alphavirus infection

Type I IFN induction by alphaviruses

Identification of steps in alphavirus propagation inhibited by host antiviral effectors

Antagonism of type I IFN responses by the alphaviruses

5: Alphaviruses and their Role in Elucidating Antiviral Responses in Mosquitoes

A historical perspective on antiviral response studies in mosquito cells using alphaviruses

Control of alphavirus replication by small RNA pathways

Immune signalling pathways and extracellular mechanisms involved in antiviral defences in mosquitoes

The role of apoptosis as mosquito antiviral response

6: Animal Models of Alphavirus-induced Inflammatory Disease

Mouse models of alphavirus disease

Non-human primate models of alphavirus disease

Alternative animal models of alphavirus disease

7: Clinical Manifestations of Arthritogenic Alphaviruses

Clinical spectrum of infections caused by arthritogenic alphaviruses

Treatment of alphavirus infection

8: Encephalitic Alphaviruses

Peripheral virus replication and innate immunity in vivo

CNS pathology and tropism of encephalitic alphaviruses

CNS immune response to alphaviruses.

9: Application of Alphavirus Vectors for Gene Therapy

Alphavirus expression vectors

Alphavirus vectors in gene therapy

10: Case Study: Chikungunya Virus

Molecular biology of CHIKV

Epidemiology of CHIKV infections

Clinical manifestations and pathology of CHIKV infections

Immune responses against CHIKV infections

Vaccines and therapy

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-910190-16-0

OCLC:

939960472