Molecular biology of kinetoplastid parasites / edited by Hemanta K. Majumder.

Format:

Book

Contributor:

Majumder, Hemanta K., editor.

Language:

English

Subjects (All):

Kinetoplastida.

Physical Description:

1 online resource (256 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Norfolk, England : Caister Academic Press, [2018]

Summary:

Written by a team of authors active in the field of Leishmania and Trypanosoma research, this volume reviews the current research in kinetoplastid parasites. With an emphasis on cellular and molecular biology, areas covered include epigenetic regulation, cellular defence, manipulation of host macrophages, B lymphocyte response, adhesion and invasion of host tissues, immune evasion, immunotherapy, hemeproteins, phospholipids biosynthesis and DNA topoisomerases. A common theme throughout the book is the identification of new therapeutic targets for drug development. This timely and up-to-date volume is essential reading for anyone working on kinetoplastid parasites and will also be of interest to parasitologists, immunologists and drug development researchers. All parasitology laboratories should have a copy of this important reference volume.

Contents:

Intro

Contents

Preface

Current Books of Interest

About the Editor

1. Genome-wide Profiling of Unique Domain Architectures Reveals Novel Epigenetic Regulators of Leishmania infantum

Introduction

Results and discussion

Conclusion

Materials and methods

2. Role of Hypoxia Inducible Factor-1 in Leishmania-Macrophage Interaction:

Structure of HIF-1

Regulation of HIF-1α

Regulation of HIF-1 activity

Role of HIF-1 in physiology

Role of HIF-1 in infection and innate immunity

HIF-1 as possible drug target in visceral form of leishmaniasis

3. Response of B Lymphocytes During Leishmania Infection

Leishmaniasis

Immune system elements

Host immune response

B-cell development and functions of B-cells

B-cell pathogenicity during Leishmania infection

Developmental deregulation of B-cells during pathological condition

Regulatory B-cells

Secretion of IL-10 from B-lymphocytes during Leishmania infection

4. Cellular Defence of the Leishmania Parasite

Distribution

Life cycle

Treatment

Challenges in the field of treatment

Parasite's defence arsenal

Host manipulation by parasite

Molecular Regulation of Macrophage Class Switching in Indian Post-kala-azar Dermal Leishmaniasis (PKDL)

Historical background of PKDL

Clinical features of PKDL

Alternative activation of macrophages and disease etiopathogenesis of PKDL

Status of cytokine milieu in dermal leishmaniasis

Toll-like receptors in PKDL

Status of reactive oxygen and nitrogen intermediates in PKDL

Attenuated phosphorylation of p-38 and ERK in PKDL

Role of host and parasite arginase 1 in PKDL

Status of co-stimulatory molecules, CD80/CD 86 in PKDL

Role of vitamin D in Indian PKDL

Status of MRC 1 in Indian PKDL.

6. Leishmania Exploits Host's Defence Machineries for Survival: A Tale of Immune Evasion

Early stages of infection

Mid stages of infection

Late stages of infection

Protecting own niche: prevention of host cell apoptosis

Ceramide in the Establishment of Visceral Leishmaniasis, an Insight into Membrane Architecture and Pathogenicity

Pathways of ceramide biosynthesis

Ceramide an important component of inflammatory response

Role of ceramide in infectious diseases

Biphasic role of ceramide during visceral leishmaniasis

Ceramide-mediated impairment in antigen presentation

Ceramide mediated regulation of kinases and phosphatises

Modulation of T-cell subsets through ceramide generation during visceral leishmaniasis

8. The Role of Haemproteins in Different Life Cycle Stages of Leishmania

Haem and haem containing proteins

Leishmania need haem for survival

Source of haem and its acquisition systems in Leishmania

Role of different types of haemproteins in eukaryotes and prokaryotes

Conclusions

Future trends

9. Pre-adaptation of Leishmania Promastigotes to Intracellular Life: Ensuring a Successful Infection

Membrane and cytoskeleton-sensing the changes

Parasite exoproteome-modulating the host

Cytosolic proteins: a pool of stress busters

The metabolic adaptations

The global picture of parasite preadaptation

Concluding remarks

10. DNA Topoisomerases of Kinetoplastid Parasites: Brief Overview and Recent Perspectives

Different topoisomerases of kinetoplastid parasites

Exploiting the topoisomerases of kinetoplastid parasites for therapeutic interventions

Conclusion and future perspectives.

11. Host-Kinetoplastid Parasite Interaction at the Immune System Interface: Immune Evasion and Immunotherapy

Molecular host-parasite interaction and strategies of immune evasion by the parasite

Morphological characterization of kinetoplastids

Leishmania

Trypanosoma

Development of immunotherapeuetics

Vaccination using parasite derived immunogenic components

12. Extracellular Matrix Interacting Proteins of Trypanosomatids: Adhesion and Invasion of Host Tissues

General overview of extracellular matrix components

Mechanism of extracellular matrix interaction by the extracellular matrix interacting proteins

Synopsis

13. Effects of Phospholipid Analogues on Trypanosomatids

Phospholipids and their importance for the cell

Phospholipids biosynthetic pathways in mammalian cells and in trypanosomatids

Design and synthesis of phospholipid analogues

Effect of phospholipid analogues on the growth and morphology of trypanosomatids

Cell death processes and immunomodulatory effects induced by phospholipid analogues

A critical view of the use of miltefosine for treatment of leishmaniasis

Index.

Notes:

Description based on print version record.

ISBN:

1-910190-72-1

OCLC:

1028552451