Microbial efflux pumps : current research / Edited by Edward W. Yu, Qijing Zhang and Melissa H. Brown.

Format:

Book

Contributor:

Yu, Edward W., editor.

Brown, Melissa H., editor.

Zhang, Qijing, editor.

Language:

English

Subjects (All):

Drug resistance in microorganisms.

Physical Description:

1 online resource (259 p.)

Edition:

1st ed.

Place of Publication:

Norfolk, England : Caister Academic Press, [2013]

Language Note:

English

Summary:

Infectious diseases caused by bacteria remain a leading cause of death worldwide. Many of the antibiotics developed to combat bacterial infections have been rendered almost impotent due to the rapid evolution and spread of antibiotic resistance. A common and major resistance mechanism - the efflux system - enables bacteria to extrude structurally diverse antimicrobials, facilitating survival in toxic environments. The pumps also have important physiological functions, play major roles in bacterial pathogenesis, and are distributed widely across diverse bacterial species. In addition, a single

Contents:

Contents; Contributors; Preface; Ch 01: Transmembrane Molecular Transporters Facilitating Export of Molecules from Cells and Organelles; Ch 02: Structures of Multidrug Efflux Pumps from the MFS, SMR, MATE and ABC Transporter Families; Ch 03: The Machinery and Mechanism of Multidrug Efflux in Gram-negative Bacteria; Ch 04: Structure, Mechanism and Assembly of the Tripartite CusCBA Heavy Metal Efflux Complex; Ch 05: RND Efflux Pumps for Metal Cations; Ch 06: The Role of Efflux Pumps in the Nosocomial Pathogens Staphylococcus aureus and Acinetobacter baumannii

Ch 07: Mycobacterium tuberculosis Drug Efflux Pumps: An UpdateCh 08: Salmonella Efflux Pumps; Ch 09: Pseudomonas aeruginosa Efflux Pumps; Ch 10: Function and Regulation of Neisseria gonorrhoeae Efflux Pumps; Ch 11: Multidrug Efflux Transporters in Campylobacter; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on print version record.

ISBN:

1-908230-86-X

OCLC:

868493206