Mechanics of biological systems : introduction to mechanobiology and experimental techniques / Seungman Park and Yun Chen.

Format:

Book

Author/Creator:

Park, Seungman, author.

Chen, Yun (Biomedical Engineer), author.

Contributor:

Morgan & Claypool Publishers, publisher.

Institute of Physics (Great Britain), publisher.

Series:

IOP (Series). Release 6.

IOP concise physics

[IOP release 6]

IOP concise physics, 2053-2571

Language:

English

Subjects (All):

Biomechanics.

Physical Description:

1 online resource (various pagings) : illustrations (some color).

Distribution:

Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, [2019]

Other Title:

Introduction to mechanobiology and experimental techniques.

Place of Publication:

San Rafael [California] (40 Oak Drive, San Rafael, CA, 94903, USA) : Morgan & Claypool Publishers, [2019]

System Details:

Mode of access: World Wide Web.

System requirements: Adobe Acrobat Reader, EPUB reader, or Kindle reader.

text file

Biography/History:

Yun Chen is an assistant professor in the Department of Mechanical Engineering, at Johns Hopkins University, MD. She is specialized in developing multi-scale, multi-modal imaging tools to study how mechanics integrates with other biophysical and biochemical factors to sustain normal physiology or to cause pathology. Seungman Park is currently a Postdoctoral Associate at Johns Hopkins University, MD. Dr. Park Received his Ph.D. degree in Mechanical Engineering from Purdue University, IN, in 2014. His research area is tissue engineering, cell mechanics, and mechanobiology. Dr. Park is a member of American Heart Association, American Physical Society, American Society of Cell Biology and Biophysical Society. He is also the awardee of Maryland Stem Cell Research Fund Fellowship.

Summary:

This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales--molecular, cellular, and tissue levels--sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Contents:

1. Force, stress, and mechanical properties in biological systems

1.1. Overview

2. Mechanics primers and theoretical models for biomaterial characterization

2.1. Overview

2.2. Force

2.3. Stress

2.4. Parameters for mechanical properties

2.5. Basic rules of mechanics

2.6. Hyperelastic models

2.7. Viscoelastic model

2.8. The poroelastic model

3. Important forces at the molecular level and how to measure them

3.1. Overview

3.2. Force generated by motor proteins

3.3. Forces generated by actin polymerization

3.4. Forces generated by microtubule polymerization

3.5. Force required for breaking intermolecular bonds

3.6. Torque

3.7. Supercoiling in DNA

3.8. Rotational energy during ATP synthesis

3.9. Force and torque measurement techniques at the molecular level

4. Important forces at the cellular level and how to measure them

4.1. Overview

4.2. Force generation, transmission, and sensing at the cellular level

4.3. Cancer metastasis

4.4. Mechanosensitive gene expression

4.5. Mechanical properties of the cell

4.6. Force and mechanical property measurements

5. Important forces at the tissue level and how to measure them

5.1. Overview

5.2. Principles of force generation and coordination at the tissue level

5.3. Mechanoresponsive processes at the tissue level

5.4. Force, stress, and mechanical property measurement techniques at the tissue level.

Notes:

"Version: 20191101"--Title page verso.

"A Morgan & Claypool publication as part of IOP Concise Physics"--Title page verso.

Includes bibliographical references.

Title from PDF title page (viewed on December 9, 2019).

Other Format:

Print version:

ISBN:

9781643273921

9781643273907

OCLC:

1130295072

Access Restriction:

Restricted for use by site license.