Drug-device combination products : delivery technologies and applications / edited by Andrew Lewis ; cover photo by Simon Condie.

Format:

Book

Contributor:

Lewis, Andrew.

Condie, Simon.

Series:

Woodhead Publishing Series in Biomaterials

Woodhead Publishing in materials

Language:

English

Subjects (All):

Drug delivery systems.

Biomedical materials.

Pharmaceutical technology.

Physical Description:

1 online resource (561 p.)

Place of Publication:

Cambridge, England ; Boca Raton, Florida : Woodhead Publishing : CRC Press, 2010.

Language Note:

English

Summary:

Drug delivery systems represent a vast area of research and development within biomaterials and medicine and the demand for sophisticated drug delivery devices continues to drive novel product development. Advanced drug delivery devices can offer significant advantages over conventional drugs and devices alone, such as increased efficiency, improved performance and convenience. The purpose of this book is to illustrate how effective drug delivery can be achieved by means other than tablets. The book will provide a thorough analysis of the fundamentals, applications and new technologies of drug

Contents:

Cover; Drug-device combination products: Delivery technologies and applications; Copyright; Contents; Contributor contact details; Preface; Part I Overview; 1 Drug-device combination products; 1.1 Introduction; 1.2 Rationale for drug device combination applications; 1.3 Drug-enhanced device products; 1.4 Device-based drug delivery systems; 1.5 Summary; 1.6 References; 2Enabling drug delivery from combination products; 2.1 Introduction; 2.2 Which drugs and why?; 2.3 Achieving controlled release from a device; 2.4 Biologic-device combinations; 2.5 Concluding remarks; 2.6 References

3Nanomedical drug-device combination products3.1 Introduction; 3.2 Nanomedical combination products (NMCPs); 3.3 Benefits of nanomedical combination products (NMCPs); 3.4 Future trends: exploring new principles for designing combination products; 3.5 References; Part II Areas of application; 4Catheter-based drug-device combination products: an overview; 4.1 Introduction; 4.2 Currentmaterials employed in catheter manufacture; 4.3 Infectious complications associated with the use of indwelling catheters; 4.4 Complications associated with urological catheters

4.5 Complications associated with central venous catheters (CVCs)4.6 Complications associated with peritoneal catheters; 4.7 Conclusion; 4.8 References; 5Catheter-based drug-device combination products: the anti-infective 5-fluorouracil-coated central venous catheter; 5.1 Introduction; 5.2 Preclinical testing; 5.3 Clinical study; 5.4 Conclusions; 5.5 References; 6Future outlook for drug eluting stents; 6.1 Introduction; 6.2 Drug eluting stents (DESs): Where are we now?; 6.3 Challenges in the use of drug eluting stents (DESs)

6.4 Strategic approaches for future use of drug eluting stents (DESs)6.5 Summary; 6.6 Acknowledgments; 6.7 References; 7Drug eluting beads in the treatment of liver cancer; 7.1 Introduction; 7.2 Embolisation therapy; 7.3 The drug eluting beads (DEBs) technology platform; 7.4 Clinical evaluation of Dox drug eluting beads (DEBs); 7.5 Interactions of drug eluting beads (DEBs) with irinotecan and comparison with Dox; 7.6 Clinical evaluation of irinotecan drug eluting beads (DEBIRIs); 7.7 Conclusions and future trends; 7.8 Acknowledgements; 7.9 References; 8 Antibiotic-loaded bone cements

8.1 Introduction8.2 The need for antibiotics in joint replacement; 8.3 The development of antibiotic-loaded cements; 8.4 Choice of antibiotic; 8.5 Performance characteristics of antibiotic-loaded bone cements; 8.6 Current products and clinical usage; 8.7 Regulatory position; 8.8 Future trends; 8.9 Conclusions; 8.10 References; 9 Glass-ionomer cements as drug-device combination products; 9.1 Introduction; 9.2 Composition and setting chemistry; 9.3 Ion release from glass-ionomer cements; 9.4 Release of antiseptics and related compounds; 9.5 Conclusions; 9.6 Acknowledgements; 9.7 References

10Bone graft substitutes as drug-device combination products

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed February 5, 2014).

ISBN:

1-61344-794-9

1-84569-748-0