The practice of medicinal chemistry / edited by Camille Georges Wermuth.

Format:

Book

Contributor:

Wermuth, C. G.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Drugs--Design.

Drugs.

Physical Description:

1 online resource (982 pages)

Edition:

3rd ed.

Place of Publication:

Amsterdam ; Boston : Elsevier/Academic Press, 2008.

Language Note:

English

Summary:

Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery

Contents:

Front Cover; The Practice of Medicinal Chemistry; Copyright Page; Contents; Biography; Section Editors; Contributors; Preface to the First Edition; Preface to the Second Edition; Preface to the Third Edition; Part I: General Aspects of Medicinal Chemistry; Chapter 1. A History of Drug Discovery; I. Introduction; A. The renewal of chemistry; B. The dawn of the organic chemistry crosses the birth of biology; II. Two Hundred Years of Drug Discoveries; A. Pain killers: best-sellers and controversies; B. Giving back the heart its youth; C. Fight against microbes and viruses

D. Drugs for immunosuppression; E. Contribution of chemists to the fight against cancer; F. Drugs for endocrine disorders; G. Anti-acid drugs; H. Lipid lowering drugs; I. From neurotransmitters to receptors; J. Drugs of the mind; III. Considerations on Recent Trends in Drug Discovery; A. From genetics to DNA technology; B. Hopes and limits for drug hunting; References; Chapter 2. Medicinal Chemistry: Definitions and Objectives, Drug Activity Phases, Drug Classification Systems; I. Definitions and Objectives; A. Medicinal chemistry and related disciplines and terms; B. Drugs and drug substances

C. Stages of drug development; II. Drug Activity Phases; A. The pharmaceutical phase; B. The pharmacokinetic phase; C. The pharmacodynamic phase; D. The road to successful drug development?; III. Drug Classification Systems; A. Classification by target and mechanism of action; B. Other classification systems; References; Chapter 3. Measurement and Expression of Drug Effects; I. Introduction; II. In Vitro Experiments; A. Binding studies; B. Ligand-receptor interaction-induced functional effects; C. Allosteric interaction; D. Expression of functional effects for targets other than GPCRS

E. Cellular and tissular functional responses; III. Ex Vivo Experiments; IV. In Vivo Experiments; References; Chapter 4. Molecular Drug Targets; I. Introduction; A. How many drug targets for how many drugs?; B. From the drug target to the response of the organism; C. Drug binding, affinity and selectivity; D. Various ligands for a single target; II. Enzymes as Drug Targets; A. Targeting human enzymes; B. Targeting enzymes selective of invading organisms; III. Membrane Transporters as Drug Targets; A. Established drug targets among membrane transporters

B. Progress in the pharmacological control of membrane transporters; IV. Voltage-Gated Ion Channels as Drug Targets; A. Voltage-gated sodium channels (Na[sub(V)] channels); B. Voltage-gated calcium channels (Ca[sub(V)] channels); C. Potassium channels; V. Non-Selective Cation Channels as Drug Targets; VI. Direct Ligand-Gated Ion Channels (Receptors with Intrinsic Ion Channel); A. P2X-ATP receptors; B. Glutamate-activated receptors; C. The ""Cys-loop receptor superfamily""; VII. Receptors with Intrinsic Enzyme Activity; A. Receptors with guanylate cyclase activity; B. Receptors with serine/threonine kinase activity

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611795443

9781281795441

1281795445

9780080568775

0080568777

OCLC:

476223366