Nanobiomaterials in hard tissue engineering : applications of nanobiomaterials / edited by Alexandru Mihai Grumezescu, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania, Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, University of Politehnica of Bucharest, Bucharest, Romania.

Format:

Book

Contributor:

Grumezescu, Alexandru Mihai, editor.

Language:

English

Subjects (All):

Nanotechnology.

Nanostructured materials.

Biomedical engineering.

Tissue Scaffolds.

Nanostructures.

Medical Subjects:

Tissue Scaffolds.

Nanostructures.

Physical Description:

1 online resource (512 p.)

Place of Publication:

Amsterdam : Elsevier, [2016]

Summary:

Nanobiomaterials in Hard Tissue Engineering covers the latest developments in the field of hard tissue engineering at the nanoscale. Leading researchers from around the world discuss the latest research and offer new insights.This book presents data about the fabrication and characterization of nanobiomaterials involved in hard tissue reconstruction, describing recent progress and the advantages of both conventional and computer-aided methods. Recent applications of different classes of nanobiomaterials are discussed, with in vitro and in vivo applications also explained in detail. Special attention is paid to the applications of nanobiomaterials in bone regeneration and in the development of functional coatings for tailored implants to improve osseointegration. Finally, the book considers future challenges and perspectives.This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.- An up-to-date and highly structured guide for researchers, practitioners and students working in biomedical, biotechnological and engineering fields- A detailed and invaluable overview of hard tissue engineering, an increasingly important field- Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology

Contents:

Front Cover; Nanobiomaterials in Hard Tissue Engineering; Copyright Page; Contents; List of contributors; Preface of the series; Preface; About the Series (I-XI); About Volume IV; 1 Nanobiomaterials in hard tissue engineering; 1.1 Introduction; 1.2 Implants and Biomaterials in Tissue Engineering; 1.2.1 Implants and Grafts, Associated Problems; 1.2.2 Biomaterials; 1.2.2.1 Resorbable membranes; 1.2.2.2 Biomaterial cytotoxicity; 1.3 Advances in Nanotechnology; 1.3.1 Titanium Oxide (TiO2); 1.3.2 Oxygen Plasma (P-O2); 1.3.3 Three-Dimensional Discs and Cylinders; 1.3.4 Three-Dimensional Spheres

1.3.4.1 Controlled release gels1.3.4.2 Carbon nanotubes; 1.4 Guided Bone Regeneration; 1.5 Experiments; 1.5.1 Assays in vitro; 1.5.1.1 Preparation of polymeric PLGA membranes; 1.5.1.2 Functionalization of polymeric membrane surfaces; 1.5.1.3 Cell cultures; 1.5.2 Assays in vivo; 1.5.2.1 Animal experimentation specimens; 1.5.2.2 Surgical procedure; 1.5.2.3 Processing of the samples; 1.6 Prospects; 1.7 Conclusions; References; 2 Applications of nanobiomaterials in hard tissue engineering; 2.1 Introduction and Background; 2.2 Biomaterials in Hard Tissue Engineering; 2.2.1 Metals and Alloys

2.2.1.1 Surface modification of metals2.2.2 Ceramics; 2.2.2.1 Injectable nHA scaffolds; 2.2.2.2 Bioglass: bioactive glass-ceramic materials; 2.2.3 Polymers; 2.2.3.1 Injectable polymer hydrogels; 2.2.3.2 Polymers for cartilage engineering; 2.2.3.2.1 Nano-rough copolymers; 2.2.3.2.2 Nanofibrous copolymers; 2.2.3.2.3 Hydrogels for cartilage replacement; 2.2.3.2.4 Surface topography of polymers of NF copolymers; 2.2.4 Composites; 2.2.4.1 nHA-reinforced polymers; 2.2.4.2 Chitosan-HA composite scaffolds; 2.3 Nanofabrication Methods; 2.3.1 Unordered Nanotopography

2.3.1.1 Solution casting and particulate leaching2.3.1.2 Thermally induced phase separation; 2.3.1.3 Gas foaming process; 2.3.1.4 Emulsion freeze-drying; 2.3.1.5 Electrospinning; 2.3.2 Ordered Nanotopography; 2.3.2.1 3D Nanoprinting; 2.3.2.2 Electrospinning; 2.3.2.3 Soft lithography; 2.3.2.3.1 Electron beam lithography; 2.3.2.3.1.1 Injection nanomolding; 2.3.2.3.1.2 Contact nanoprinting/hot embossing; 2.4 Conclusions; References; 3 Emerging trends of nanobiomaterials in hard tissue engineering; 3.1 Introduction; 3.1.1 Scaffold for TE; 3.1.2 Nanobiomaterials in Hard Tissue Engineering

3.1.2.1 Hydroxyapatite3.1.2.2 Metal nanoparticles; 3.1.2.3 Carbon nanostructures; 3.1.2.4 Nanocomposite films; 3.1.2.5 Porous scaffolds; 3.1.2.6 Nanohybrid membranes; 3.2 Applications of Nanobiomaterials in Therapies; 3.2.1 Bone Regeneration; 3.2.2 Cartilage regeneration; 3.2.3 Bone Implants for Load-Bearing Applications; 3.2.4 Dental Tissue Regeneration; 3.2.4.1 Endodontic regeneration; 3.2.4.2 Periodontal regeneration; 3.2.5 Tooth Regeneration; 3.3 Conclusions; References; Further Reading

4 Nanostructured materials as substrates for the adhesion, growth, and osteogenic differentiation of bone cells

Notes:

Includes index.

Description based on online resource; title from PDF title page (ebrary, viewed March 14, 2016).

ISBN:

9780323428859

0323428851

9780323428620

0323428622