Nanobiomaterials : nanostructured materials for biomedical applications / edited by Roger Narayan.

Format:

Book

Contributor:

Narayan, Roger, editor.

Language:

English

Subjects (All):

Nanostructures.

Biomedical materials.

Physical Description:

1 online resource (563 pages) : illustrations

Place of Publication:

Duxford, England : Woodhead Publishing, 2018.

Summary:

Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined.- Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials- Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials- Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials

Contents:

Front Cover

Nanobiomaterials: Nanostructured Materials for Biomedical Applications

Copyright

Contents

List of contributors

Chapter 1: Nanostructured ceramics

1.1 Introduction

1.2 Test methods for nanostructured ceramics

1.2.1 Micro/nanostructural evaluation

1.3 Nanostructured bioceramics

1.3.1 Low temperature chemical bonding

1.3.2 Why nanostructures in chemically bonded ceramics?

1.3.3 Nanostructures in the Ca-aluminate-Ca-phosphate system (CAPH)

1.4 Application field of nanostructured bioceramics

1.4.1 Dental applications including coating products

1.4.2 Orthopedic applications

1.4.3 Drug delivery carrier applications

1.5 Conclusion and summary

Acknowledgement

References

Chapter 2: Bio-based nanostructured materials

2.1 Introduction

2.2 Polysaccharide-based nanomaterials

2.2.1 Chitin

2.2.2 Chitosan

2.2.3 Cellulose

2.3 Carbon

2.4 Clay

2.5 Plant proteins

2.6 Keratin

2.7 Phage

2.8 Natural bioceramics

2.9 Conclusion and future trends

Chapter 3: Self-assembled nanomaterials

3.1 Introduction

3.2 Why self-assembled nanomaterials?

3.3 Polymer-based self-assembled carriers

3.3.1 Polymeric nanoparticles

3.3.1.1 Nanospheres

3.3.1.2 Nanocapsules

3.3.1.3 Nanogels

3.3.1.4 Polymeric micelles

3.3.1.5 Polymersomes

3.3.1.6 Liquid crystals

3.3.1.7 Dendrimers

3.4 Lipid-based self-assembled carriers

3.4.1 Liposomes

3.4.2 Solid lipid nanoparticles

3.4.3 Lipid nanocapsules

3.4.4 Microemulsions

3.4.5 Self-microemulsifing drug delivery systems

3.5 Concluding remarks and future perspectives

Chapter 4: Nanowires for biomedical applications

4.1 Introduction

4.2 Fabrication

4.3 Biocompatibility

4.4 Application

4.4.1 Neural interface

4.4.2 Tissue engineering.

4.4.3 Force sensing

Further reading

Chapter 5: [60]Fullerene and derivatives for biomedical applications

5.1 Introduction

5.2 Physicochemical properties

5.3 Physical properties responsible of the main biological effects

5.3.1 Shape and size

5.3.2 Singlet oxygen (1O2) formation

5.3.3 Free-radical scavenging

5.4 Potential biomedical applications

5.4.1 Enzyme inhibition

5.4.2 Imaging and radiotherapy

5.4.3 Photodynamic therapy

5.4.4 Free-radical scavenging

5.4.5 Miscellaneous

5.5 Toxicity, pharmacokinetics, metabolism, and excretion

5.5.1 Toxicity

5.5.1.1 Toxicity studies on pristine C60

5.5.1.2 Toxicity of noncovalently modified C60

5.5.1.3 Toxicity of covalently modified C60

5.5.2 Pharmacokinetics, metabolism and excretion

5.5.2.1 Studies on unmodified C60

5.5.2.2 Studies on C60 derivatives

5.6 Conclusion

Chapter 6: Self-assembled monolayers in biomaterials

6.1 Introduction

6.1.1 Scope of this chapter

6.2 Self-assembled monolayers

6.2.1 Chemical modification of gold surfaces by the SAMs

6.2.1.1 SAMs preparation and structure

6.2.1.2 Kinetic studies of the SAM formation

6.2.1.3 Single/mono and mixed SAMs

6.2.1.4 Factors governing the formation of SAMs

6.2.1.5 Characterization of the SAMs

6.2.1.6 Effect of alkanethiols SAMs on protein adsorption and cell behavior

6.2.2 Organosilane-based SAMs on silicon surfaces

6.2.2.1 Factors affecting the formation of organosilane SAMs

Water

Temperature

Solvent

6.2.2.2 Interface properties: wettability, surface tension, topography and potential

6.2.2.3 Modifications of SAMs and patterning

Click chemistry

Nucleophilic substitution

Supramolecular modification

SAMs patterning

6.2.2.4 Biomolecules' behavior on silane SAMs-modified surfaces.

Protein adsorption

Cell adhesion

6.2.3 SAMs based on long polymers

6.2.3.1 Polymeric SAMs

Biomolecules at polymer brushes

6.3 Conclusion

Chapter 7: Nanostructured surfaces in biomaterials

7.1 Introduction

7.2 Surface modification methods of titanium

7.3 Bulk nanostructured titanium

7.4 Bulk titanium-bioceramic nanocomposites

7.5 Nanostructured surfaces

7.6 Antibacterial activity of nanostructured Ti-45S5 Bioglass-Ag composite

7.7 Conclusion

Chapter 8: Magnetic nanoparticle synthesis

8.1 Introduction

8.2 Production of magnetic nanoparticles

8.2.1 Mechanical milling

8.2.2 Co-precipitation

8.2.3 Nanoreactors/microemulson techniques

8.2.4 Sonochemical processing

8.2.5 Sol-gel methods

8.2.6 Flow injection

8.2.7 Electrochemical production

8.2.8 Supercritical fluid techniques

8.2.9 Thermal decomposition

8.2.10 Hydrothermal routes

8.2.11 Microwave techniques

8.2.12 Spray pyrolysis

8.2.13 Laser pyrolysis

8.2.14 Flame spray pyrolysis

8.2.15 Gas phase synthesis

8.2.16 Arc discharge

8.2.17 Oxidation

8.2.18 Microbial methods

8.3 Stabilization/coating methods

8.3.1 Polymers

8.3.2 Precious metals

8.3.3 Silica

8.3.4 Carbon

8.3.5 Oxidation

8.3.6 Physical encapsulation

8.4 Conclusions

Chapter 9: Toxicity of nanostructured biomaterials

9.1 Nanotoxicology: Concepts and claims

9.2 Dose and dosimetry of nanobiomaterials

9.3 Surface topography of nanobiomaterials and associated surface reactivity

9.4 NPs and the environment

9.5 Interfaces between nanobiomaterials and target cells

9.6 Routes of entry of nanobiomaterials

9.7 Effect of nanobiomaterials on biomolecules

9.8 Nanobiomaterials and their effect on DNA.

9.9 In vivo toxicology of nanobiomaterials in humans: Prospective mechanisms

9.10 Toxicity of different nanostructured biomaterials

9.10.1 Gold NPs

9.10.2 Silver NPs

9.10.3 Silica NPs

9.10.4 Selenium NPs

9.10.5 Titanium dioxide NPs

9.10.6 Zinc oxide NPs

9.10.7 Cerium oxide NPs

9.10.8 Polymeric NPs

9.10.9 Carbonaceous NPs

9.10.9.1 Carbon nanotubes

9.10.9.2 Graphene

9.11 Future scope and conclusion

Acknowledgments

Chapter 10: Use of nanostructured materials in hard tissue engineering

10.1 Introduction

10.2 The intricacies of hard tissue architecture and engineering considerations

10.2.1 Hard tissue cellular composition

10.2.2 Composition of hard tissue extracellular matrix

10.2.3 Considerations for intelligence in biomimicry of the extracellular matrix for a rational approach to hard tiss ...

10.3 Fabrication approaches for designing nanostructured materials for hard tissue engineering

10.4 Integration of diverse approaches and biomaterials for the design of nanostructured material scaffolds for bone ...

10.4.1 Electrospun nanofiber-based scaffolds

10.4.2 Nanofiber-based scaffolds via thermally induced phase separation

10.4.3 Nanocrystalline hydroxyapatite-based scaffolds via combinatory lyophilization approaches

10.4.4 Bioactive glass-based nanostructured composites via the sol-gel process

10.4.5 Magnetically synthesized carbon nanotube-structured scaffolds via lyophilization

10.4.6 Nanodiamond-structured scaffolds via solvent evaporation/solvent casting

10.4.7 Magnetic nanoparticle-structured biomimetic scaffolds

10.4.8 Nanostructured scaffolds via rapid prototyping technologies

10.5 Integration of diverse approaches and biomaterials for the design of nanostructured material scaffolds for denta ...

10.5.1 Nanostructured materials for enamel regeneration

10.5.2 Nanostructured materials for pulpodentinal complex regeneration

10.5.3 Nanostructured materials for periodontal apparatus regeneration

10.5.4 Nanostructured materials for whole tooth regeneration

10.6 Conclusions, challenges, and proposed future advances for nanostructured materials in hard tissue engineering

Chapter 11: Nanobiomaterials in dentistry

11.1 Introduction to nanotechnology in dentistry

11.1.1 Definition

11.1.2 Types

11.1.3 Applications of nanotechnology

11.2 Nanotechnology in dentistry

11.2.1 Research

11.2.1.1 Tissue engineering and stem cells

11.2.2 Preventive dentistry

11.2.2.1 Decontamination, disinfection, and sterilization

11.2.2.2 Toothpaste and mouthwash

11.2.2.3 Caries prevention

11.2.3 Conservative dentistry and prosthodontics

11.2.3.1 Introduction to anesthetics

11.2.3.2 Bonding materials

11.2.3.3 Impression materials

11.2.3.4 New composite materials

11.2.4 Periodontics, oral surgery and implants

11.2.4.1 Early disease diagnosis

11.2.4.2 Oral cancer diagnosis and treatment

11.2.4.3 Needles in cell surgery

11.2.4.4 Tissue regeneration

11.2.4.5 Acceleration of the healing process

11.2.4.6 Dental implant surfaces

Bone-implant interface

11.2.5 Orthodontics

11.2.5.1 Reduction of orthodontic forces

11.2.5.2 Bonding properties

11.2.5.3 Antibacterial and anticarious properties

11.2.5.4 Orthodontic treatment time reduction

11.3 Discussion and conclusions

11.3.1 Problems and advantages

Chapter 12: Use of nanostructured materials in medical diagnostics

12.1 Zero-dimensional (0-D) nanostructured materials

12.1.1 Introduction

12.1.2 Synthesis

12.1.3 Property.

12.1.4 Surface modification and bioconjugation of QDs.

Notes:

Includes bibliographical references at the end of each chapters and index.

Description based on online resource; title from PDF title page (ebrary, viewed October 16, 2017).

ISBN:

9780081007259

0081007256

9780081007167

0081007167