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Function and regulation of the PDK1 kinase / Dario Alessi.
- Format:
- Video
- Author/Creator:
- Alessi, Dario, speaker, author.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Protein phosphorylation.
- Protein phosphorylation, 2056-452X
- Language:
- English
- Subjects (All):
- Phosphorylation.
- Protein Serine-Threonine Kinases.
- Medical Subjects:
- Phosphorylation.
- Protein Serine-Threonine Kinases.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (58 min.)) : color, sound.
- polychrome
- Place of Publication:
- London : Henry Stewart Talks, 2010.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: The insulin cascade
- Approaches to study the insulin signalling pathway
- GSK3 regulation of glycogen synthase by insulin
- Inactivation of GSK3 by PI3K
- GSK3 inactivation by other kinases
- Protein Kinase B (Akt)
- PKB signal transduction
- Substrate specificity of PKB
- Activation of PKB by insulin
- Phosphorylation of PKB on Thr308 and Ser473
- PKB phosphorylation on the catalytic domain
- How insulin locates PKB to the plasma membrane
- PKB translocation to the cell membrane
- Molecular mechanism of PKB activation
- Phosphorylation of PKB
- Discovery of PDK1
- Primary structure of human PDK1
- PIP3 requirement for PDK1 activation of PKB
- PDK1/2 phosphorylation of PKB
- The inability of PIP3 to activate PDK1 in vitro
- PKB in muscle-specific PDK1 knockout mice
- Glycogen synthase inactivation by GSK3
- GSK3 and glycogen synthase in muscle-specific PDK1 knockout mice
- GSK3 knock-in mice
- Analysis of GSK3 isoforms in knock-in mice
- Glycogen synthase activity in knock-in mice
- Insulin effects mediated by protein kinases
- S6K, SGK and PKC activation
- PDK1 as a "master upstream kinase"
- S6K in muscle-specific PDK1 knockout mice
- PDK1 activation of 24 AGC kinase members
- Regulation of the PDK1 pathway
- The PDK1 kinase domain
- Defining the PIF-pocket by knock-in mutation
- S6K in PDK1 PIF-pocket knock-in mutation
- The role of PIP3 binding to the PH domain
- Inhibition of PKB in PDK1 PH domain knock-in cells
- The role of the PDK1 in cancer
- Evaluation of PDK1 as a drug target
- Generation of PDK1 hypomorphic mice
- PTEN and its effect in cancer
- PDK1 and PTEN in tumours.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 2827 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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