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Inhibiting protein-protein interactions : part 1 of 2 / Adrian Whitty.
- Format:
- Video
- Author/Creator:
- Whitty, Adrian, (Boston University, USA), speaker, author.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Small molecule drug discovery.
- Small molecule drug discovery, 2056-452X
- Language:
- English
- Subjects (All):
- Drug development.
- Drug targeting.
- Protein-protein interactions.
- Proteins--Inhibitors.
- Proteins.
- Drug Design.
- Protein Binding--drug effects.
- Protein Interaction Mapping.
- Proteins--antagonists & inhibitors.
- Proteins--metabolism.
- Small Molecule Libraries--pharmacology.
- Medical Subjects:
- Drug Design.
- Protein Binding--drug effects.
- Protein Interaction Mapping.
- Proteins--antagonists & inhibitors.
- Proteins--metabolism.
- Small Molecule Libraries--pharmacology.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (41 min.)) : color, sound.
- polychrome
- Other Title:
- Inhibiting protein-protein interactions. Part 1
- Place of Publication:
- London : Henry Stewart Talks, 2014.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: The druggable proteome
- Objectives
- Five propositions about the druggability of PPI targets
- Classification of PPI targets
- Why are small molecule inhibitors of PPI hard to obtain?
- PPI topology can vary widely
- Classification of PPI interfaces
- Druggability
- Fragment-based lead identification
- Empirical measures of druggability
- Factors affecting druggability
- Computational assessment of PPI druggability with FTMAP
- Evaluating PPI using FTMAP
- Nature of druggable sites in PPI.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3676 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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