1 option
Epigenetically mediated gene silencing : a companion to genetic alterations in driving tumorigenesis / Stephen Baylin.
- Format:
- Video
- Author/Creator:
- Baylin, Stephen B., speaker, author.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.
- Epigenetics : concepts, theories, paradigms and mechanisms, 2056-452X
- Language:
- English
- Subjects (All):
- Epigenesis, Genetic.
- Gene Expression Regulation, Neoplastic.
- Gene Silencing.
- Medical Subjects:
- Epigenesis, Genetic.
- Gene Expression Regulation, Neoplastic.
- Gene Silencing.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (68 min.)) : color, sound.
- polychrome
- Other Title:
- Epigenetically mediated gene silencing : tumorigenesis
- Place of Publication:
- London : Henry Stewart Talks, 2007.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: Introduction to epigenetic changes in cancer
- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer
- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes
- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer
- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis
- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis
- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 1038 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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