EGF receptor family : targets for cancer therapeutics / Tony Burgess.

Format:

Video

Author/Creator:

Burgess, Antony, 1946- speaker, author.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease.

Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease, 2056-452X

Language:

English

Subjects (All):

Cells.

Receptor Protein-Tyrosine Kinases.

ErbB Receptors.

Signal Transduction.

Tumor Cells, Cultured.

Medical Subjects:

Cells.

Receptor Protein-Tyrosine Kinases.

ErbB Receptors.

Signal Transduction.

Tumor Cells, Cultured.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (45 min.)) : color, sound.

polychrome

Other Title:

Title on publisher web site: Signaling from the EGF receptor family in normal and cancer cells

Place of Publication:

London : Henry Stewart Talks, 2007.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: The association of the Epidermal Growth Factor Receptor (EGFR) with the tumorigenic state

The four related members of the EGFR family (EGFR, erbB2, erbB3 and erbB4)

Signaling of the activated receptors as either homo- or heteromeric oligomers

Activation of the EGFR by excess ligand stimulation, receptor over-expression and/or mutation in many carcinomas

Utility of antibodies and receptor kinase inhibitors which interfere with signaling from the EGFR family as agents in cancer therapy

The three-dimensional structures for the extracellular domains of EGFR, erbB2, erbB3 and erbB4 and the discovery that EGFR, erbB3 and erbB4 undergo major conformational transitions when interacting with their ligands

Development of antibodies (mab806) which reduce tumor formation from cells expressing either truncated D2-7 EGFR or over-expressed EGFR by binding to the receptor in a region normally masked by the dimerization of the EGFR extracellular domain

Use of EGFR antagonists or inhibitors to increase tumor killing by cytotoxic anti-cancer drugs and/or radiation

Improvement of tumor killing by combining EGFR antagonists and EGFR kinase inhibitors.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

1074 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.