Colorectal cancer and the rare variant hypothesis / Walter Bodmer.

Format:

Video

Author/Creator:

Bodmer, W. F. (Walter Fred), 1936- Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Human population genetics I : evolution and variation.

Human population genetics I : evolution and variation, 2056-452X

Language:

English

Subjects (All):

Colorectal Neoplasms--genetics.

Genetics, Population.

Medical Subjects:

Colorectal Neoplasms--genetics.

Genetics, Population.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (53 min.)) : color, sound.

polychrome

Place of Publication:

London : Henry Stewart Talks, 2007.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: Cancer: a somatic evolutionary process

Colorectal cancer: a good model to study

Two clear cut familial forms: FAP and HNPCC

Mutation selection balance for dominants and recessives: application to FAP

APC gene found by positional cloning

Loss of heterozygosity proved its role in sporadic cancers

Selection for mutations in the APC "mutation cluster region"

HNPCC mismatch repair genes found by candidate guess

Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence

Arguments for and against need for genomic instability in cancers

Epigenetic changes

Mathematical model of normal and cancerous crypt

Types of familial cancers: mostly rarer than FAP and HNPCC

Approaches to studying multifactorial inherited susceptibility

HLA and disease: the model

Role of linkage disequilbrium

Principles of SNP association analysis

Rare missense variants in the APC gene confer susceptibility

The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

1557 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.