Cross-genomic analysis of human disease genes / Ethan Bier.

Format:

Video

Author/Creator:

Bier, Ethan, Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function'.

The legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function', 2056-452X

Language:

English

Subjects (All):

Drosophila--genetics.

Medical Subjects:

Drosophila--genetics.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (65 min.)) : color, sound.

polychrome

Place of Publication:

London : Henry Stewart Talks, 2008.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approximately 30% are highly conserved sequences

The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes

Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system

Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome

Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis

LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third

EF inhibits PKA dependent Hedgehog signaling in the fly wing.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

1780 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.