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Maintaining the silenced state of master regulatory genes during development / Bob Kingston.
- Format:
- Video
- Author/Creator:
- Kingston, Robert (Harvard University, USA), Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.
- Epigenetics, chromatin, transcription and cancer, 2056-452X
- Language:
- English
- Subjects (All):
- Chromosomal proteins.
- Developmental genetics.
- Epigenesis.
- Gene silencing.
- Genetic regulation.
- Drosophila Proteins--metabolism.
- Epigenesis, Genetic.
- Gene Expression Regulation, Developmental.
- Gene Silencing.
- Polycomb-Group Proteins.
- Repressor Proteins--metabolism.
- Transcription Factors--metabolism.
- Medical Subjects:
- Drosophila Proteins--metabolism.
- Epigenesis, Genetic.
- Gene Expression Regulation, Developmental.
- Gene Silencing.
- Polycomb-Group Proteins.
- Repressor Proteins--metabolism.
- Transcription Factors--metabolism.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (54 min.)) : color, sound.
- polychrome
- Place of Publication:
- London : Henry Stewart Talks, 2014.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: Gene repression in cell division
- Early homeotic gene expression patterns
- The polycomb group
- Mutants of polycomb fail to maintain repression
- Transcriptional memory
- Core functional PcG complexes
- Regulation of PRC2 in drosophila and humans
- PRC2 core subunits in humans
- Prominent modifications that can occur
- Chromodomains bind H3 tail marks
- Differential chromodomain binding
- Targeting of the PcG complexes
- Drosophila PREs are bound by PHO
- Mechanisms involved in targeting
- Mammalian HOX clusters are a key PRC1 target
- Human D11.12 is similar to fly PREs
- CpG islands and long non-coding RNAs
- Small RNAs specifying repression
- Noncoding RNAs influence chromatin structure
- Mode of repression
- How are genes silenced?
- PRC1 in compaction and ubiquitylation
- Nucleosome dynamics
- Characteristics of the compaction domain
- Gene silencing by chromatin compaction
- The SIR complex and mating type silencing
- Structural rearrangements in NCP and BAH
- Folding events in Sir3 BAH/NCP complex
- The nucleosome as a silencing machinery
- Epigenetic memory.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3513 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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