Drug discovery and target validation in the p53 pathway / David Lane.

Format:

Video

Author/Creator:

Lane, David, 1952- Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Cell division cycle : controlling when and where cells divide and differentiate.

The cell division cycle : controlling when and where cells divide and differentiate, 2056-452X

Language:

English

Subjects (All):

Cell Cycle.

Genes, cdc.

Medical Subjects:

Cell Cycle.

Genes, cdc.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (40 min.)) : color, sound.

polychrome

Place of Publication:

London : Henry Stewart Talks, 2009.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: Controlling cancer

p53 discovery

Oncoproteins

SV40, Adeno and HPV

The p53 protein

Incidence of genetic changes in p53 in human cancers

What does p53 do?

The p53 pathway is blocked in many tumor cells

p53 and HDM2 are connected by a negative feedback loop

Mdm2 controls p53

Evidence for the fine regulation of the p53 response

How does p53 cause advanced aging?

Therapy approaches

Gene therapy

Activating p53

Targets for p53 activation

Small peptides block p53/HDM interaction and activate p53

Peptide minimization and optimization

Nutlin 3 specificity

Thousands of compounds can be tested for their ability to activate p53-dependent transcription

CYC202: a cdk inhibitor in clinical trial that is a non genotoxic activator of the p53 response

CDK inhibition

Regulation of p53 by ubiquitin like proteins

Stress stimuli that control the activity of p53

New isoforms of p53.

Notes:

Animated audio-visual presentation with synchonized narration.

Title from title frames.

Publisher Number:

2379 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.