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Nonsense-mediated and Staufen1-mediated mRNA decay : related pathways of post-transcriptional control in mammalian cells / Lynne E. Maquat.
- Format:
- Video
- Author/Creator:
- Maquat, Lynne, Speaker.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation.
- From DNA to proteins : the multiple levels of regulation, 2056-452X
- Language:
- English
- Subjects (All):
- Cellular control mechanisms.
- Genetic regulation.
- Messenger RNA.
- RNA stability.
- Cytoskeletal Proteins--physiology.
- Eukaryotic Initiation Factors--metabolism.
- Exons.
- Nonsense Mediated mRNA Decay.
- Protein Isoforms.
- RNA Cap-Binding Proteins.
- RNA Processing, Post-Transcriptional.
- RNA Splicing.
- RNA Stability.
- RNA, Double-Stranded.
- RNA, Messenger.
- RNA-Binding Proteins.
- Medical Subjects:
- Cytoskeletal Proteins--physiology.
- Eukaryotic Initiation Factors--metabolism.
- Exons.
- Nonsense Mediated mRNA Decay.
- Protein Isoforms.
- RNA Cap-Binding Proteins.
- RNA Processing, Post-Transcriptional.
- RNA Splicing.
- RNA Stability.
- RNA, Double-Stranded.
- RNA, Messenger.
- RNA-Binding Proteins.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (40 min.)) : color, sound.
- polychrome
- Other Title:
- Nonsense-mediated and Staufen1-mediated messenger RNA decay : related pathways of post-transcriptional control in mammalian cells
- RNA surveillance
- Place of Publication:
- London : Henry Stewart Talks, 2007.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: Three core Upf NMD factors
- Exon junction complexes (EJCs)
- Upf1
- Mechanism of NMD
- Activation of EJC-bound Upf1
- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins
- NMD downregulating functional protein isoforms
- Restriction to newly synthesized mRNAs during a pioneer round of translation
- Cap Binding Protein (CBP) heterodimer CBP80-CBP20
- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA
- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2
- Staufen (Stau)1-mediated mRNA decay (SMD)
- Double-stranded RNA binding protein Stau1
- Mechanism of action of SMD.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 1165 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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