The generation of diversity in antibody genes / Michael Neuberger.

Format:

Video

Author/Creator:

Neuberger, M. S. (Michael S.), Speaker.

Series:

Henry Stewart talks. Biomedical & life sciences collection. Monoclonal antibodies as therapeutic agents : fundamentals, therapeutic applications and latest advances.

Monoclonal antibodies as therapeutic agents : fundamentals, therapeutic applications and latest advances, 2056-452X

Language:

English

Subjects (All):

Antibodies, Monoclonal--therapeutic use.

Medical Subjects:

Antibodies, Monoclonal--therapeutic use.

Genre:

Video recordings.

Physical Description:

1 online resource (1 streaming video file (60 min.)) : color, sound.

polychrome

Place of Publication:

London : Henry Stewart Talks, 2007.

System Details:

Mode of access: World Wide Web.

video file

Contents:

Contents: Historical perspective on antibodies and immunity

Nature and structure of antibodies and immunoglobulin fold

Theories of antibody formation

Clonal selection theory

Mechanisms contributing to antibody diversity

Organization of immunoglobulin loci

Immunoglobulin gene rearrangement and generation of the primary repertoire

RSS elements

RAG genes and mechanism of V-D-J joining

Membrane immunoglobulin and the B-cell antigen receptor

Secondary antibody repertoire and diversification of rearranged immunoglobulin genes

Affinity maturation

Somatic hypermutation, gene conversion and class-switch recombination

DNA deamination as a central trigger for these three diversification processes

Detailed pathways of antibody gene diversification

AID and the evolution of DNA deamination.

Notes:

Animated audio-visual presentation with synchronized narration.

Title from title frames.

Publisher Number:

1208 Henry Stewart Talks

Access Restriction:

Restricted for use by site license.