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Discovery of Levetiracetam (Keppra(R)) : the first SV2A ligand for the treatment of epilepsy / Henrik Klitgaard.
- Format:
- Video
- Author/Creator:
- Klitgaard, Henrik, speaker, author.
- Series:
- Henry Stewart talks. Biomedical & life sciences collection. Drug discovery and development in the neurosciences.
- Henry Stewart talks. Biomedical & life sciences collection. Small molecule drug discovery.
- Drug discovery and development in the neurosciences, 2056-452X
- Small molecule drug discovery, 2056-452X
- Language:
- English
- Subjects (All):
- Anticonvulsants.
- Convulsions--Chemotherapy.
- Convulsions.
- Drug development.
- Epilepsy--Chemotherapy.
- Epilepsy.
- Anticonvulsants--pharmacology.
- Anticonvulsants--therapeutic use.
- Drug Discovery.
- Epilepsy--drug therapy.
- Molecular Targeted Therapy.
- Piracetam--pharmacology.
- Seizures--drug therapy.
- Medical Subjects:
- Anticonvulsants--pharmacology.
- Anticonvulsants--therapeutic use.
- Drug Discovery.
- Epilepsy--drug therapy.
- Molecular Targeted Therapy.
- Piracetam--pharmacology.
- Seizures--drug therapy.
- Genre:
- Video recordings.
- Physical Description:
- 1 online resource (1 streaming video file (35 min.)) : color, sound.
- polychrome
- Place of Publication:
- London : Henry Stewart Talks, 2013.
- System Details:
- Mode of access: World Wide Web.
- video file
- Contents:
- Contents: Levetiracetam
- Antiepileptic Drug Discovery
- Levetiracetam in electroshock and PTZ seizures
- Protection against seizures in rat model
- Levetiracetam activity in GAERS model
- Impact on cognitive function
- Hyper-synchronization / excitability inhibition in vitro
- Effect on development of amygdala kindling
- Effect on seizures in genetic models of epilepsy
- Inactivation of sodium channels
- Reduction of current through T-type Ca channels
- Levetiracetam mechanism of action
- SV2 proteins: candidates for the LEV binding site
- SV2A cloning and binding studies
- Levetiracetam studies in SV2A (+/-) mice
- Profile of new class of antiepileptic drugs.
- Notes:
- Animated audio-visual presentation with synchronized narration.
- Title from title frames.
- Publisher Number:
- 3569 Henry Stewart Talks
- Access Restriction:
- Restricted for use by site license.
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