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Mitochondrial replacement techniques : ethical, social, and policy considerations / Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases, Board on Health Sciences Policy, Institute of Medicine ; Anne Claiborne, Rebecca English and Jeffrey Kahn, editors.
- Format:
- Book
- Author/Creator:
- Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases, Corporate Author.
- Language:
- English
- Subjects (All):
- Mitochondrial DNA.
- Mitochondrial pathology.
- Physical Description:
- 1 online resource (201 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Washington, D.C. : National Academies Press, [2016]
- Language Note:
- English
- Summary:
- Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.
- Contents:
- Pages:1 to 25; Pages:26 to 50; Pages:51 to 75; Pages:76 to 100; Pages:101 to 125; Pages:126 to 150; Pages:151 to 175; Pages:176 to 200; Pages:201 to 201
- Notes:
- Description based upon print version of record.
- Description based on print version record.
- ISBN:
- 9780309388733
- 0309388732
- 9780309388719
- 0309388716
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