Helicobacter pylori Research : From Bench to Bedside / edited by Steffen Backert, Yoshio Yamaoka.

Format:

Book

Contributor:

Backert, Steffen, editor.

Yamaoka, Yoshio, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Medical microbiology.

Immunology.

Gastroenterology.

Bacteriology.

Medical Microbiology.

Local Subjects:

Medical Microbiology.

Immunology.

Gastroenterology.

Bacteriology.

Physical Description:

1 online resource (XI, 613 pages) : 57 illustrations, 52 illustrations in color

Edition:

First edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Tokyo : Springer Japan : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

This book provides the current updated knowledge on all essential aspects in the rapidly evolving area of Helicobacter pylori research. H. pylori is a class I carcinogen and one of the most common infections in the world. While most people colonized by H. pylori will remain asymptomatic, up to 20 % of them may develop serious gastroduodenal disease such as peptic ulcers or gastric cancer. H. pylori is the only known bacterium linked to the development of cancer and consequently is an important focus of research. Outstanding international experts from diverse scientific disciplines contribute here to give detailed insights into the current understanding concerning the physiology and role of this pathogen. Both basic science and clinical research with actual practical consequences are taken into account. The chapters target microbiology, epidemiology, genetics, biochemistry, interactions with the immune system, signal transduction, pathogenic mechanisms in the gastroduodenal mucosa, gastric disease development, and therapy including antibiotics or probiotics treatment as well as vaccination strategies. This book is an important reference not only for clinicians but also microbiologists. It provides in a single volume an up-to-date summary of our current knowledge of this microbe and the multiple ways in which it impacts upon public health in all parts of the world.

Contents:

PART 1 BACTERIOLOGY AND MOLECULAR BIOLOGY

1 Helicobacter pylori: genetics, recombination, population structure and human migrations

2 Adaptation of Helicobacter pylori metabolism to persistent gastric colonization

3 Virulence mechanisms of Helicobacter pylori: an overview

4 Roles of the cagPAI and CagA on gastroduodenal diseases

5 Helicobacter pylori vacuolating toxin

6 Roles of the BabA and the SabA adhesins in gastroduodenal diseases

7 Emerging novel virulence factors of Helicobacter pylori

8 The primary transcriptome and non-coding RNA repertoire of Helicobacter pylori

9 Genome evolution: Helicobacter pylori as an extreme model

10 Non-Helicobacter pylori Helicobacter infections in humans and animals

PART 2 IMMUNE RESPONSES AND HOST FACTORS

11 Animal Models of Helicobacter pylori Infection

12 Helicobacter pylori and the host immune response

13 The role of inflammatory responses in mouse gastric tumorigenesis

14 Influence of host gene polymorphisms on development of gastroduodenal diseases

PART 3 HELICOBACTER PYLORI-ASSOCIATED DISEASES

15 Helicobacter pylori and Nonmalignant Diseases

16 Helicobacter pylori and gastrointestinal polyps

17 Helicobacter pylori infection and gastric cancer

18 Helicobacter pylori infection and MALT lymphoma

19 Helicobacter pylori infection in children

PART 4 TREATMENT OF HELICOBACTER PYLORI

20 Helicobacter pylori therapy

21 Management of H. pylori infection in Europe

22 Population-based strategies for Helicobacter pylori-associated disease management: Latin American perspective

23 Population-based strategies for Helicobacter pylori-associated disease management: Asian perspective

24 Probiotics as an alternative therapy for Helicobacter pylori-associated diseases

25 Vaccination against Helicobacter pylori infection.

Other Format:

Printed edition:

ISBN:

978-4-431-55936-8

9784431559368

Access Restriction:

Restricted for use by site license.