The Alkali Metal Ions: Their Role for Life / edited by Astrid Sigel, Helmut Sigel, Roland K. O. Sigel.

Format:

Book

Contributor:

Sigel, Astrid, editor.

Sigel, Helmut, editor.

Sigel, Roland K. O., editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Metal ions in life sciences 1559-0836 ; 16.

Metal Ions in Life Sciences, 1559-0836 ; 16

Language:

English

Subjects (All):

Biochemistry.

Biochemistry, general.

Local Subjects:

Biochemistry, general.

Physical Description:

1 online resource (XLI, 628 pages) : 194 illustrations, 114 illustrations in color.

Edition:

First edition 2016.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2016.

System Details:

text file PDF

Summary:

MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Contents:

Bioinorganic Chemistry of the Alkali Metal Ions

Determination of Alkali Ions in Biological and Environmental Samples

Solid State Structures of Alkali Metal Ion Complexes Formed by Low-Molecular-Weight Ligands of Biological Relevance

Discriminating Properties of Alkali Metal Ions towards the Constituents of Proteins and Nucleic Acids. Conclusions from Gas-Phase and Theoretical Studies

Alkali Metal Ion Complexes with Phosphates, Nucleotides, Amino Acids, and Related Ligands of Biological Relevance. Their Properties in Solution

Sodium and Potassium Interactions with Nucleic Acids

Role of Alkali Metal Ions in G-Quadruplex Nucleic Acid Structure and Stability

Sodium and Potassium Ions in Proteins and Enzyme Catalysis

Roles and Transport of Sodium and Potassium in Plants

Potassium versus Sodium Selectivity in Monovalent Ion Channel Selectivity Filters

Sodium as Coupling Cation in Respiratory Energy Conversion

Sodium-Proton (Na+/H+) Antiporters: Properties and Roles in Health and Disease

Proton-Potassium (H+/K+) ATPases: Properties and Roles in Health and Diseases

Bioinspired Artificial Sodium and Potassium Ion Channels

Lithium in Medicine: Mechanisms of Action

Sodium and Potassium Relating to Parkinson's Disease and Traumatic Brain Injury.

Other Format:

Printed edition:

ISBN:

978-3-319-21756-7

9783319217567

Access Restriction:

Restricted for use by site license.