Protein Kinase CK2 Cellular Function in Normal and Disease States / edited by Khalil Ahmed, Olaf-Georg Issinger, Ryszard Szyszka.

Format:

Book

Contributor:

Ahmed, Khalil, 1934- editor.

Issinger, O. G., editor.

Szyszka, Ryszard, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Advances in biochemistry in health and disease ; 12.

Advances in Biochemistry in Health and Disease ; 12

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Proteins.

Apoptosis.

Cancer Research.

Protein Science.

Local Subjects:

Cancer Research.

Protein Science.

Apoptosis.

Physical Description:

1 online resource (XXIII, 378 pages) : 91 illustrations, 60 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

The field of protein kinases has greatly impacted our understanding of the basic mechanisms in cell function. The field has also been a major focus of drug development that considers the broad reach of the protein kinase function under diverse conditions. One member of the kinome, protein kinase CK2, continues to emerge as a major signaling molecule involved in diverse functions in health and disease. This kinase has unique features, most notably its ubiquitous and highly conserved nature. Its vast number of potential substrates exemplifies its involvement in various functions in cells under both the normal and diseased states. Of particular note is the observation that due to its ubiquitous nature, CK2 has been found to be dysregulated in all cancers that have been examined. As such, it is now being considered a potentially important target for cancer therapy. Protein Kinase CK2 plays equally important functions in development and intracellular activities, and has a global impact on cell growth and proliferation. An additional key function of CK2 is the impact of its activity on cell death processes. Given the vast nature of its functions, CK2 has been proposed to serve as a "master regulator" of cell function. The chapters included in this work cover a wide range of topics dealing with some of the functions mentioned above, providing an important starting point for research investigators and graduate students interested in this field.

Contents:

1. CK2 Suppression of Apoptosis

2. Structural Determinants of CK2 Regulation

3. Targeting Protein Kinase: CK2 Suppresses Pro-Survival Signaling Pathways and Growth of Gliobastoma

4. The Roles of CK2 in Drosophila Neurogenesis

5. Targeting the CK2 Subunit Interface: Challenge and Usefulness

6. CK2 in Wnt/β-catenin signaling and embryo development

7. Defective expression of CK2β promotes EMT and stemness properties both required for breast cancer progression

8. Chemical Biology Approaches to Identify CK2 Substrates and Perform Unbiased Evaluation of CK2 Inhibitors

9. Development of Screening Systems and Identification of Novel Potent Inhibitors of Human Protein Kinase CK2

10. Protein Kinase CK2: At the Crossroad of Regulatory Cellular Pathways

11. Functional Regulation of DYRK Family Protein Kinases by Cellular Binding Partners

12. Regulation of CK2 in pancreatic β cells

13. Recent impressions from the configurational and conformational space captured by protein kinase CK2

14. Role of CK2 in Plant Responses to Abiotic Stress

15. "Genuine" Casein Kinase: The False Sister of CK2: Phosphorylates-Secreted Proteins

16. CK2: - A Novel Player in L-DOPA induced dyskinesia in a mouse model of Parkinson's disease

17. CK2 function in the regulation of Akt Pathway: new findings and perspectives

18. CK2 structure from yeast to human

19. Cellular zinc signaling is triggered by CK2

20. A Nanomedicine Approach to Targeting CK2 for Cancer therapy

21. Bisubstrate approach for construction of high-affinity inhibitors and optical probes for protein kinase CK2.

Other Format:

Printed edition:

ISBN:

978-3-319-14544-0

9783319145440

Access Restriction:

Restricted for use by site license.