Next Generation Sequencing in Cancer Research, Volume 2 : From Basepairs to Bedsides / edited by Wei Wu, Hani Choudhry.

Format:

Book

Contributor:

Wu, Wei (Editor), editor.

Choudhry, Hani, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Language:

English

Subjects (All):

Cancer--Research.

Cancer.

Human genetics.

Bioinformatics.

Cancer Research.

Human Genetics.

Local Subjects:

Cancer Research.

Human Genetics.

Bioinformatics.

Physical Description:

1 online resource (XVIII, 493 pages) : 78 illustrations, 70 illustrations in color

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides, the second in the series "Next Generation Sequencing Technology in Cancer Research-From Basepairs to Bedsides," is designed to fill the gap between cancer genome research and clinical management of the individual cancer patient. The volume presents the principles of next generation sequencing (NGS) technologies and massively parallel DNA sequencing and their application of the whole genome sequences (WGS), whole exome-seq (WES), RNA-seq, miRNA-seq, and ChIP-seq in cancer research programs and to apply the newly discovered driver genetic alterations for prevention, early diagnosis and genome-oriented precision cancer treatment. Next Generation Sequencing in Cancer Research, Volume 2: From Basepairs to Bedsides brings together the implementation of a wide range of NGS technologies, including single-cell sequencing, in the clinical setting: discovery and validation of cancer biomarkers; standardization of NGS data production; NGS data reporting systems for clinicians; novel anti-cancer therapies development from NGS data; conducting of clinical trials of newly investigated cancer drugs. It provides compelling evidence to signal a new future for health care and a new standard for cancer care.

Contents:

Single-cell next Generation Sequencing and Its Applications in Cancer Biology

Utility of Next Generation Sequencing in Cancer Drug Development and Clinical Trials

Next-Generation Sequencing in the Era of Cancer-Targeted Therapies: Towards the Personalised Medicine

Mutational Similarities Across Cancers: Implications for Research, Diagnostics and Personalized Therapy Design

Standardized Decision Support in NGS Reports of Somatic Cancer Variants

Clinical Considerations in the Conduct of Cancer Next Generation Sequencing Testing and Genetic Counselling

Next Generation Sequencing for Cancer Biomarker Discovery

Validation and Implementation of Next Generation Sequencing Technologies in a Clinical Molecular Diagnostic Laboratory

Next Generation Sequencing Technologies and Formalin Fixed Paraffin Embedded Tissue: Application to Clinical Cancer Research

Applications of NGS to Screen FFPE Tumours for Detecting Fusion Transcripts

Clinical Application of Next-Generation Sequencing of Formalin-Fixed Paraffin-Embedded Tumors

ChIP-BS-Sequencing in Cancer Epigenomics

Integrative Analysis Identifies Transcription Factor-DNA Methylation Relationships and Introduces New Avenues for Translating Cancer Epigenetics Into the Clinic

Differential Methylation Analysis with Next-Generation Sequencing

Performance Comparison and Data Analysis Strategies for MicroRNA Profiling in Cancer Research

Small RNA Sequencing for Squamous Cell Carcinoma Research

Exome Capture and Capturing Technologies in Cancer Research

The Landscape of DNA Virus Associations Across Human Malignant Cancers

Using Next Generation Sequencing to Reveal Patterns of Chromosomal Alterations in Oral Verrucous Carcinoma

Vironomics: The Study of Viral Genomics in Human Cancer and Disease

Molecular Typing of Lung Adenocarcinoma on Cytological Samples in the Next Generation Sequencing Era

Whole Genome/Exome Sequencing in Acute Leukemia: From Research to Clinics

Next Generation Sequencing Applications in Head and Neck Oncology

CIC Mutation in Brain Tumor

Isocitrate Dehydrogenase (IDH) Mutation in Gliomas

Utilization of Multigene Panels in Hereditary Cancer Predisposition Testing.

Other Format:

Printed edition:

ISBN:

978-3-319-15811-2

9783319158112

Access Restriction:

Restricted for use by site license.