Free Radicals in ENT Pathology / edited by Josef Miller, Colleen G. Le Prell, Leonard Rybak.

Format:

Book

Contributor:

Miller, Josef, 1860- editor.

Le Prell, Colleen G., editor.

Rybak, Leonard, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Oxidative stress in applied basic research and clinical practice 2197-7224

Oxidative Stress in Applied Basic Research and Clinical Practice, 2197-7224

Language:

English

Subjects (All):

Oxidative stress.

Otolaryngology.

Pathology.

Oxidative Stress.

Otorhinolaryngology.

Local Subjects:

Oxidative Stress.

Otorhinolaryngology.

Pathology.

Physical Description:

1 online resource (XIV, 507 pages) : 43 illustrations, 32 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Humana, 2015.

System Details:

text file PDF

Summary:

This comprehensive volume examines the current state of free radical biology and its impact on otology, laryngology, and head and neck function. The chapters collectively highlight the interrelationship of basic and translational studies in each area, define the challenges to translation, and identify the existing basic issues that demand investigation as well as the opportunities for novel intervention to prevent and treat ENT pathology and impairment. In each chapter, or in some cases pairs of chapters, the author(s) have included or married issues of basic research with translational challenges and research, thus defining the pathway by which new basic insights may lead to interventions to prevent or treat impairment. The final chapter of this book reflects a meeting of all the contributors, culminating in a discussion and "white paper" that identifies the challenges to the field and defines the studies and collaborations that may lead to improved understanding of free radical biology in ENT and, subsequently, new interventions to medically treat ENT pathology.

Contents:

1. Introduction

Section 1: Basic Science of Free Radical Biology in ENT

2. Free radicals and oxidative stress: Basic concepts and misconceptions

3. A Question of Balance: Free Radicals and Cochlear Homeostasis

4. Antioxidants and their effect on stress-induced pathology in the inner ear

Section 2: Epidemiology of Hearing Loss

5. Role of free radicals in hearing loss due to heavy metals

6. The role of nutrition in healthy hearing: human evidence

Section 3: Oxidative Stress and Noise-Induced Hearing Loss

7. Basic mechanisms underlying noise-induced hearing loss

8. Oxidative stress in noise-induced hearing loss

9. Strategies for evaluating antioxidant efficacy in clinical trials assessing prevention of noise-induced hearing loss

Section 4: Oxidative Stress and Drug-Induced Hearing Loss

10. Aminoglycoside-induced oxidative stress: pathways and protection

11. Hearing loss after cis-platin: oxidative stress pathways and potential for protection

12. Assessment of interventions to prevent drug-induced hearing loss (DIHL)

Section 5: Oxidative Stress and Age-Related Hearing Loss

13. Age-related hearing loss: biochemical pathways and molecular targets

14. Genetics and age-related hearing loss

15. Mechanisms of age-related hearing loss

16. Interventions to prevent age-related hearing loss

Section 6. Hereditary Hearing Loss

17. Genes and hearing loss: relationship to oxidative stress and free radical formation

18. Strategies for the treatment of hereditary hearing loss

Section 7: Cochlear Implants, Radiation, Trauma and Other Stress Factors

19. Loss of Residual Hearing Initiated by Cochlear Implantation: Role of Inflammation-Initiated Cell

20. Role of oxidative stress in sudden hearing loss and Meniere's disease

Section 8: Head and Neck

21. Role of free radicals in head and neck pathology

22. Free radicals and sleep apnea

23. Free radicals in nasal and paranasal disease

24. Conclusion.

Other Format:

Printed edition:

ISBN:

978-3-319-13473-4

9783319134734

Access Restriction:

Restricted for use by site license.