Multifaceted Roles of Crystallography in Modern Drug Discovery / edited by Giovanna Scapin, Disha Patel, Eddy Arnold.

Format:

• Book

Contributor:

• Scapin, Giovanna, editor.
• Patel, Disha, editor.
• Arnold, Eddy, editor.
• SpringerLink (Online service)

Series:

• Biomedical and Life Sciences (Springer-11642)
• NATO science for peace and security series. Chemistry and biology 1874-6489 Series A,
• NATO Science for Peace and Security Series A: Chemistry and Biology, 1874-6489

Language:

English

Subjects (All):

• Proteins.
• Pharmaceutical chemistry.
• Molecular biology.
• Chemistry, Physical and theoretical.
• Crystallography.
• Protein-Ligand Interactions.
• Medicinal Chemistry.
• Molecular Medicine.
• Theoretical and Computational Chemistry.
• Crystallography and Scattering Methods.

Local Subjects:

• Protein-Ligand Interactions.
• Medicinal Chemistry.
• Molecular Medicine.
• Theoretical and Computational Chemistry.
• Crystallography and Scattering Methods.

Physical Description:

1 online resource (XI, 240 pages) : 107 illustrations, 89 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

The present work offers a snapshot of the state-of-the-art of crystallographic, analytical, and computational methods used in modern drug design and development. Topics discussed include: drug design against complex systems (membrane proteins, cell surface receptors, epigenetic targets, and ribosomes); modulation of protein-protein interactions; the impact of small molecule structures in drug discovery and the application of concepts such as molecular geometry, conformation, and flexibility to drug design; methodologies for understanding and characterizing protein states and protein-ligand interactions during the drug design process; and monoclonal antibody therapies. These methods are illustrated through their application to problems of medical and biological significance, such as viral and bacterial infections, diabetes, autoimmune disease, and CNS diseases. As approaches to drug discovery have changed over time, so have the methodologies used to solve the varied, new, and difficult problems encountered in drug discovery. In recent years we have seen great progress in the fields of genetics, biology, chemistry, and medicine, but there are still many unmet medical needs, from bacterial infections to cancer to chronic maladies, that require novel, different, or better therapies. This work will be of interest to researchers and policy makers interested in the latest developments in drug design.

Contents:

• Preface
• List of Contributors
• Engineering G Protein-Coupled Receptors for Drug Design
• Structural Insights into Activation and Allosteric Modulation of G Protein-Coupled Receptors
• Epigenetic Drug Discovery
• Crystallography and Biopharmaceuticals
• Structural Chemistry and Molecular Modeling in the Design of DPP4 Inhibitors
• Considerations for Structure-Based Drug Design Targeting HIV-1 Reverse Transcriptase.-Protein-Ligand Interactions as the Basis for Drug Action
• The Protein Data Bank: Overview and Tools for Drug Discovery
• Small Molecule Crystal Structures in Drug Discovery
• Protein Aggregation and its Prediction
• Importance of Protonation States for the Binding of Ligands to Pharmaceutical Targets
• Protein-Protein Interactions: Structures and Druggability
• Achieving High Quality Ligand Chemistry in Protein-Ligand Crystal Structures for Drug Design
• Molecular Obesity, Potency and Other Addictions in Drug Discovery
• Adventures in Small Molecule Fragment Screening by X-ray Crystallography for Drug Discovery
• Structure-Based Drug Design to Perturb Function of a tRNA-Modifying Enzyme by Active Site and Protein-Protein Interface Inhibition
• Molecular Interaction Analysis for Discovery of Drugs Targeting Enzymes and for Resolving Biological Function.

Other Format:

Printed edition:

ISBN:

• 978-94-017-9719-1
• 9789401797191

Access Restriction:

Restricted for use by site license.