Subunit Vaccine Delivery / edited by Camilla Foged, Thomas Rades, Yvonne Perrie, Sarah Hook.

Format:

Book

Contributor:

Foged, Camilla, editor.

Rades, Thomas, editor.

Perrie, Yvonne, editor.

Hook, Sarah, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Advances in delivery science and technology 2192-6204

Advances in Delivery Science and Technology, 2192-6204

Language:

English

Subjects (All):

Pharmaceutical technology.

Vaccines.

Medicine.

Pharmaceutical Sciences/Technology.

Vaccine.

Biomedicine, general.

Local Subjects:

Pharmaceutical Sciences/Technology.

Vaccine.

Biomedicine, general.

Physical Description:

1 online resource (XIV, 431 pages) : 65 illustrations, 48 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

New York, NY : Springer New York : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration-in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Contents:

1 Immunological Background

2 Classification of Vaccines

3 Aluminum Adjuvants - Basic Concepts and Progress in Understanding

4 Emulsions as Vaccine Adjuvants

5 The application of liposomes as vaccine adjuvants

6 Developing Bilayer-based Delivery Systems for Oral Delivery of Subunit Vaccines

7 Cubosomes - Structure, Preparation and Use as an Antigen Delivery System

8 ISCOMs as a Vaccine Delivery System

9 Virus-like Particles, a Versatile Subunit Vaccine Platform

10 Polymeric Particulates for Subunit Vaccine Delivery

11 Gels as Vaccine Delivery Systems

12 Implants as Sustained Release Delivery Devices for Vaccine Antigens

13 Dendritic Cell-based Vaccines

14 Parenteral Vaccine Administration - Tried and True

15 Nasal Administration of Vaccines

16 Pulmonary Administration of Subunit Vaccines

17 Vaginal Delivery of Subunit Vaccines

18 Transcutaneous Administration

19 Pharmaceutical Analysis and Quality Control of Vaccines

20 The Physical Analysis of Vaccines

21 Characterizing the Association between Antigens and Adjuvants.

Other Format:

Printed edition:

ISBN:

978-1-4939-1417-3

9781493914173

Access Restriction:

Restricted for use by site license.