Genome Mapping and Genomics in Human and Non-Human Primates / edited by Ravindranath Duggirala, Laura Almasy, Sarah Williams-Blangero, Solomon F.D. Paul, Chittaranjan Kole.

Format:

Book

Contributor:

Duggirala, Ravindranath, editor.

Almasy, Laura, editor.

Williams-Blangero, Sarah, editor.

Paul, Solomon F. D., editor.

Kole, Chittaranjan, editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Genome mapping and genomics in animals 2512-3394 ; 5.

Genome Mapping and Genomics in Animals, 2512-3394 ; 5

Language:

English

Subjects (All):

Animal genetics.

Gene expression.

Evolution (Biology).

Animal Genetics and Genomics.

Gene Expression.

Evolutionary Biology.

Local Subjects:

Animal Genetics and Genomics.

Gene Expression.

Evolutionary Biology.

Physical Description:

1 online resource (VIII, 305 pages) : 39 illustrations, 10 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

This book provides an introduction to the latest gene mapping techniques and their applications in biomedical research and evolutionary biology. It especially highlights the advances made in large-scale genomic sequencing. Results of studies that illustrate how the new approaches have improved our understanding of the genetic basis of complex phenotypes including multifactorial diseases (e.g., cardiovascular disease, type 2 diabetes, and obesity), anatomic characteristics (e.g., the craniofacial complex), and neurological and behavioral phenotypes (e.g., human brain structure and nonhuman primate behavior) are presented. Topics covered include linkage and association methods, gene expression, copy number variation, next-generation sequencing, comparative genomics, population structure, and a discussion of the Human Genome Project. Further included are discussions of the use of statistical genetic and genetic epidemiologic techniques to decipher the genetic architecture of normal and disease-related complex phenotypes using data from both humans and non-human primates.

Contents:

The Utility of Genomics for Studying Primate Biology

The Human Genome Project: Where Are We Now and Where Are We Going?

Linkage Mapping: Localizing the Genes that Shape Human Variation

Association Studies to Map Genes for Disease-Related Traits in Humans

Gene Expression Studies and Complex Diseases

Copy Number Variations and Chronic Diseases

Applications of Genomic Methods to Studies of Wild Primate Populations

Comparative Genomics: Tools for Study of Complex Diseases

Genetic Structure and Its Implications for Genetic Epidemiology: Aleutian Island Populations

Mapping Genes in Isolated Populations: Lessons from the Old Order Amish

Genetics of Cardiovascular Disease in Minority Populations

Mapping of Susceptibility Genes for Obesity, Type 2 Diabetes, and the Metabolic Syndrome in Human Populations

Genetic Influence on the Human Brain

Variation, Genetics, and Evolution of the Primate Craniofacial Complex

Genetic Influences on Behavior in Nonhuman Primates

Genomic Studies of Human Populations: Re-sequencing Approaches to the Identification of Human Quantitative Loci.

Other Format:

Printed edition:

ISBN:

978-3-662-46306-2

9783662463062

Access Restriction:

Restricted for use by site license.