Single Cell Sequencing and Systems Immunology / edited by Xiangdong Wang.

Format:

Book

Contributor:

Wang, Xiangdong (Professor of clinical bioinformatics), editor.

SpringerLink (Online service)

Series:

Biomedical and Life Sciences (Springer-11642)

Translational bioinformatics 2213-2775 ; 5.

Translational Bioinformatics, 2213-2775 ; 5

Language:

English

Subjects (All):

Immunology.

Systems biology.

Proteomics.

Cytology.

Systems Biology.

Cell Biology.

Local Subjects:

Immunology.

Systems Biology.

Proteomics.

Cell Biology.

Physical Description:

1 online resource (XI, 177 pages) : 89 illustrations, 62 illustrations in color.

Edition:

First edition 2015.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2015.

System Details:

text file PDF

Summary:

The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author's personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China. .

Contents:

Preface

Significance of Single Cell Sequencing in Future Medicine

Uncovering Phenotypes with Supercells: Applications to Single-Cell Sequencing

Single-Cell Sequencing of Microorganisms

Application of single-cell sequencing in dynamic transcriptomes

System Immunology in Metabolic Research of Dendritic Cells

FOXP3+ Treg Cells and Systems Biology Approaches to Studying Their Function

γδT Cells and αβT Cells

Prolymphocyte: Lymphocytes and Bioinformatics

Lymphocytes in liver cancer

Early biomarkers of hepatocyte necrosis

Protocol of Single Cell Isolation by Flow Cytometry

Single-cell based omics-the new era of human disease and medicine

Cancer bioinformatics. .

Other Format:

Printed edition:

ISBN:

978-94-017-9753-5

9789401797535

Access Restriction:

Restricted for use by site license.